6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
PyBOP (149 mg, 287 muiotaetaomicronIota) was added to a mixture of quinoxaline-5-carboxylic acid (45.4 mg, 261 muiotaetaomicronIota), 8-amino-2-(3-chlorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 1 , Intermediate I50) (80.0 mg, 287 muiotaetaomicronIota) and N,N-diisopropylethylamine (180 muIota, 1 .0 mmol) in DMF (2.6 ml) and the mixture was stirred over night at room temperature. For work-up, water (45 ml) and methanol (2 ml) were added and the mixture was stirred for 4 h. The precipitate was collected by filtration, washed with a mixture of water and methanol (4:1 ) and dried to give the title compound 109 mg (93 % yield).LC-MS (Method 1 ): Rt= 1 .22 min; MS (ESIpos): m/z = 435 [M+H]+ 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .494 (2.45), 1 .506 (2.64), 1 .524 (2.94), 1 .535 (2.88) 1 .555 (1 .60), 1 .566 (1.50), 1 .650 (1 .19), 1.660 (1 .47), 1.683 (10.64), 1.706 (3.13), 1 .714 (3.63) 2.012 (3.13), 2.023 (3.32), 2.046 (3.09), 2.055 (2.76), 2.081 (5.42), 2.099 (9.45), 2.116 (5.61 )2.327 (0.87), 2.518 (2.62) 2.523 (1.85), 2.669 (0.91 ), 2.729 (0.63), 2.888 (0.76), 3.804 (5.72) 3.813 (1 .63), 3.822 (9.67) 3.829 (1.66), 3.839 (5.52), 3.888 (1.32), 3.898 (1 .62), 3.907 (1 .29) 3.917 (1 .57), 3.927 (1 .22) 7.189 (3.31 ), 7.191 (3.67), 7.194 (3.70), 7.196 (3.56), 7.209 (3.89) 7.21 1 (4.22), 7.214 (4.32) 7.216 (4.10), 7.394 (5.26), 7.415 (9.49), 7.435 (5.33), 7.589 (3.61 ) 7.591 (3.98), 7.594 (3.89) 7.596 (3.88), 7.610 (3.00), 7.61 1 (3.01 ), 7.615 (3.35), 7.617 (2.95) 7.910 (5.41 ), 7.916 (10.28), 7.921 (5.48), 7.960 (5.22), 7.977 (5.64), 7.981 (6.35), 7.999 (5.99) 8.253 (6.1 1 ), 8.257 (6.58), 8.274 (5.36), 8.278 (5.38), 8.430 (6.23), 8.433 (6.27), 8.448 (5.77) 8.452 (5.22), 9.069 (7.93), 9.074 (16.00), 9.080 (15.91 ), 9.084 (7.60), 9.770 (4.17), 9.788 (4.13), 6924-66-9
The synthetic route of 6924-66-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider