With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25983-13-5,6,7-Dichloroquinoxaline-2,3(1H,4H)-dione,as a common compound, the synthetic route is as follows.
General procedure: 2,2?-Bipyridine (0.071 g, 0.455 mmol) was added to a solution containing 0.100 g (0.454 mmol) of Cr(CO)6 in 50 mL of THF. The mixture was refluxed for 2 h with continuous stirring. The resulting orange colored solution was cooled down to room temperature. DCQX (0.104 g, 0.450 mmol) was dissolved in 20 mL of EtOH and slowly added to the reaction mixture. The contents were refluxed for 18 h with continuous stirring, and during this time the brown solid product separated from solution. The solid was isolated, washed with 15 mL THF/EtOH (1:1) and dried in vacuum. A concentrated solution of the product in DMSO/EtOH (3:1) was allowed to evaporate slowly for 2 weeks, which resulted in a reddish-brown powder. Washing the powdery solid with EtOH followed by diethyl ether and then drying overnight in vacuum resulted in 0.13 g (59.6% yield) of the pure product (one brown spot in a TLC test). Attempts to obtain crystals suitable for X-ray crystallography were unsuccessful due to the limited solubility of the synthesized complex in most common solvents. Anal. Calc. for C40H34Cl4Cr2N8O6 (Mr = 968.55): C, 49.60; H, 3.54; Cl, 14.64; N, 11.57. Found: C, 49.53; H, 3.52; Cl, 14.70; N, 11.62%. Effective magnetic moment at 298 K, mueff (BM): 2.955., 25983-13-5
The synthetic route of 25983-13-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Attia, Attia S.; Abdel Aziz, Ayman A.; Alfallous, Khalifa A.; El-Shahat; Polyhedron; vol. 51; 1; (2013); p. 243 – 254;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider