With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.879-65-2,2-Quinoxalinecarboxylic acid,as a common compound, the synthetic route is as follows.,879-65-2
Method III N,N’-Carbonyldiimidazole (13.95 g) and 2-quinoxalinecarboxylic acid (15 g) in tetrahydrofuran (600 ml) were heated under reflux for 2 hours. 5-Amino-1H-tetrazole (7.32 g) in tetrahydrofuran (36 ml) and dimethylformamide (24 ml) was added and the mixture was heated under reflux for 50 minutes. The solvent was distilled off under reduced pressure and the residue was dissolved in water (300 ml). The solution was acidified to pH2 with dilute hydrochloric acid and the solid was collected and crystallized from dimethylformamide. It had m.p. 284-285 (d) (70%).
As the paragraph descriping shows that 879-65-2 is playing an increasingly important role.
Reference£º
Patent; Allen & Hanburys Limited; US3997535; (1976); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider