6924-66-9,6924-66-9, Quinoxaline-5-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
PyBOP (100 mg, 193 muiotaetaomicronIota) was added to a mixture of 8-amino-2-(3,5-difluorophenyl)-2- azaspiro[4.5]decan-1-one (isomer 1; Intermediate I28) (50.0 mg, 161 muiotaetaomicronIota), quinoxaline-5- carboxylic acid (30.8 mg, 177 muiotaetaomicronIota) and N,N-diisopropylethylamine (140 muIota, 800 muiotaetaomicronIota) in DMF (1.8 ml) and the mixture was stirred over night at room temperature. For work-up, the reaction mixture was concentrated and the residue was stirred with methanol. The precipitate was collected by filtration, washed with water and methanol and then dried to give the title compound 53.5 mg (76 % yield).LC-MS (Method 1): Rt= 1.23 min; MS (ESIpos): m/z = 437 [M+H]+1H-NMR (400 MHz, DMSO-d6): delta [ppm] = 9.78 (d, 1H), 9.10-9.05 (m, 2H), 8.44 (dd, 1H), 8.27 (dd, 1H), 7.98 (dd, 1H), 7.56-7.48 (m, 2H), 7.02 (tt, 1H), 3.96-3.78 (m, 3H), 2.14-2.00 (m, 4H), 1.75-1.62 (m, 4H),
6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; EIS, Knut; WAGNER, Sarah; SUeLZLE, Detlev; VON NUSSBAUM, Franz; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philipp; (248 pag.)WO2018/78005; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider