91-19-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91-19-0,Quinoxaline,as a common compound, the synthetic route is as follows.
Step 11 -(quinoxalin-2-yl)ethanone (JS110)Quinoxaline (1 .1864 g, 9.1 1 mmol), Pyruvic acid (1.90 ml, 27.3 mmol), AgN03 (0.124 g, 0.73 mmol), N2H8S208 (3.12 g, 13.67 mmol) and H2S04 (0.49 ml, 9.1 1 mmol) were stirred in 1 :1 CH2CI2/H20 (150 ml) at 40 C for 2 ? h. The solution was then basified via the addition of NaOH and the organics extracted (3x) and washed brine, dried (MgS04), filtered and solvent removed. Flash chromatography (Pet Ether; 3:1 Pet Ether/EtOAc) afforded the title compound as a yellow solid (617.5 mg, 3.91 mmol, 42.9%). Mpt: 70-74 C [Lit.( J. Org. Chem., 1991 , 56, 2866-2869) 76-97 C]; Rf = 0.24 (3:1 Pet Ether/EtOAc); IR (vmax/cm”1, thin film): 1689 (CO stretch), 1357; 1H NMR (500 MHz, CDCI3): deltaEta = 2.84 (s, 3H, 12-H), 7.82-7.90 (m, 2H, 7,8-H), 8.14-8.21 (m, 2H, 6,9-H), 9.47 (s, 1 H, 3-H); 13C NMR (125 MHz, CDCI3): 5C = 25.6 (C-12), 129.5 (C-6), 130.5 (C-8), 130.8 (C-9), 132.3 (C-7), 141 .1 (C-10), 143.1 (C-3), 143.9 (C-5), 146.6 (C- 2), 199.8 (C-11 ); LRMS m/z (El+): 172 [M]+, 130 [M-Ac]+, 86; HRMS m/z (El+): Found 172.06372; Ci0H8N2O requires 172.0631 1 ; Anal. Calcd. for Ci0H8N2O: C, 69.76; H, 4.68; N, 16.27. Found C, 69.28; H, 4.56; N, 16.00%.
The synthetic route of 91-19-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin; WO2012/168733; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider