887590-25-2,887590-25-2, tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate (17 g, 72.6 mmol) in MeCN (150 mL) was added N-bromosuccinimide (12.3 g, 68.9 minol) by portionwise at 0 C. The mixture was stirred at 0 C for I h. The reaction was quenched with water (200 mE), extracted with EtOAc (200 mE x 3). The combined organic layers were dried over anhydrousNa2SO4, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography (petroleum ether / EtOAc 20: 1 to 4: 1) to give the title compound (14.0 g, 62%) as a light yellow solid. ?H NMR (400 MHz, DMSO-d6) 8 7.50 (s, iH), 6.95 – 6.92 (m, 1H), 6.52 – 6.50 (m, IH), 6.29 (s, 1H), 3.58 – 3.56 (m, 2H), 3.24 – 3.23 (m, 2H), 1.45 (s, 9H).
887590-25-2 tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate 16740533, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ROMERO, F. Anthony; MAGNUSON, Steven; PASTOR, Richard; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy; CRAWFORD, Terry; ALBRECHT, Brian, K.; COTE, Alexandre; TAYLOR, Alexander, M.; LAI, Kwong Wah; CHEN, Kevin, X.; BRONNER, Sarah; ADLER, Marc; EGEN, Jackson; LIAO, Jiangpeng; WANG, Fei; CYR, Patrick; ZHU, Bing-Yan; KAUDER, Steven; (0 pag.)WO2016/86200; (2016); A1;,
Quinoxaline – Wikipedia
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