With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32601-86-8,2-Chloro-3-methylquinoxaline,as a common compound, the synthetic route is as follows.
Preparation 19: 2-methyl-3-F4- (PHenVLmethVL) piperazin-1-ylLQUINOXALINE 2-Chloro-3-methylquinoxaline (1.0 g, 5.6 MMOL) and N-benzylpiperazine (2.9 ML, 16.8 MMOL) were mixed and heated to 125 C for 18 h. Saturated aqueous sodium hydrogen carbonate was added and the product was extracted with chloroform. The combined organic extracts were dried (NA2SO4) and concentrated in vacuo to give a dark red oil. The crude product was purified by flash chromatography using silica gel eluting with methanol : dichloromethane (15: 85) to give the pure product as a red oil which solidified upon standing (1.63 g, 94%)., 32601-86-8
32601-86-8 2-Chloro-3-methylquinoxaline 236276, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/72086; (2004); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider