With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1210048-05-7,7-Bromo-5-fluoroquinoxaline,as a common compound, the synthetic route is as follows.
Under an argon atmosphere, 750 mg (0.819 mmol) of tris-(dibenzylidene-acetone)-dipalladium(0) and 551 mg (1.966 mmol) of tricyclohexylphosphine were dissolved in 80 ml dioxane. |814 mg – -(15.019 mmol) of 4,4,414’5,5,5’5′-octamethyl-2,2t-bi-l,3,2-dioxaborolan, 3100 mg (13.654 mmol) of the compound from example 9OA and 2010 mg (20.4813 mmol) potassium acetate were added and the mixture was stirred overnight at 800C. After cooling, dioxane was added to the reaction mixture and it was filtered on Celite. The filtrate was concentrated in a rotary evaporator at reduced pressure and dried under high vacuum. We obtained 7.08 g of the raw product (purity 69% according to GC-MS), which was reacted further without further purification.GC-MS (method 6): R, = 6.78 min; MS (EIpos): m/z = 274 [M]+., 1210048-05-7
1210048-05-7 7-Bromo-5-fluoroquinoxaline 59286334, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider