With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49568-68-5,3-Chloroquinoxaline-2-carbaldehyde,as a common compound, the synthetic route is as follows.
0.3 mmol of 3-chloro-quinoxaline-2-carboxaldehyde (57.8 mg), 0.3 mmol of ammonium persulfate (68.5 mg) and 0.09 mmol of copper triflate (32.6 mg) were added to a 15 mL thick-walled pressure-resistant reaction tube. In addition, 3 mL of acetonitrile and 30 muL of water were added as a solvent. Then, magnetic stirring was carried out at 60 C for 6 hours, and two kinds of column chromatography silica gel (100-200 mesh) were added to the obtained reaction liquid, and the solvent was removed by distillation under reduced pressure, and the obtained crude product was separated by silica gel column chromatography. And the volume ratio is 10:1The mixture of petroleum ether and ethyl acetate was eluted as an eluent, and the elution progress was followed by TLC, and the eluate containing the desired product was collected, and the solvent was combined to evaporate the solvent to give the desired product. This material was a white solid with a yield of 70%.
49568-68-5, The synthetic route of 49568-68-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang University of Technology; Liu Yunkui; Bao Hanyang; Liu Lianyan; (16 pag.)CN109422700; (2019); A;,
Quinoxaline – Wikipedia
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