36856-91-4, 2-Bromoquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-Bromoquinoxaline 50 (350 mg, 1.67 mmol, 1 eq) was dissolved in EtOAc (16 ml). Octanal (1.05 ml,6.715 mmol, 4 eq) and TMSN3 (0.44 ml, 6.698 mmol, 2 eq) were added. Phi(OCOCF3)2 (1.44 g, 6.698mmol, 2 eq) was added portionwise over 10 min and the mixture turned orange in colour. The mixturewas stirred at room temperature for 2 h. Further TMSN3 (0.44 ml, 6.698 mmol, 2 eq) and Phi(OCOCF3)220 (1.44 g, 6.698 mmol, 2 eq) were added and reaction was stirred for 18 h. Triethylamine (2 ml) was addeddropwise and the mixture was stirred for 15 min. The reaction mixture was concentrated and the crudemixture was purified by silica gel column chromatography (50:1 pentane: EtOAc) to afford product 51 as ayellow solid (259 mg, 61%). Rt = 0.38 (10:1 cyclohexane: EtOAc); m.p. = 43-48 oc; 1H NMR (400 MHz,CDCI3) o 8.16-8.04 (m, 2H), 7.90-7.81 (m, 2H), 3.18 (t, J = 7.5 Hz, 2H), 1.83-1.75 (m, 2H), 1.44-25 1.28 (m, 8H), 0.89 (t, J = 7.0 Hz, 3H); 13C NMR (101 MHz, CDCI3) o 201.5, 149.8, 143.3, 139.6, 134.8,132.6, 131.2, 129.8, 128.61, 40.7, 31.8, 29.3, 29.2, 23.7, 22.8, 14.2; IR (CHCI3) (vmax, cm-1) 3429, 1708,1560; HRMS (ESI) [M + Hf calc 335.0759 for C16H20N20 79Br, found 335.0759., 36856-91-4
The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITY COLLEGE DUBLIN; GUIRY, Patrick; GODSON, Catherine; (148 pag.)WO2018/33642; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider