With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2958-87-4,2,3,6-Trichloroquinoxaline,as a common compound, the synthetic route is as follows.
EXAMPLE 2 9-Chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline and 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline A mixture of 23.3 g. of 2,3,6-trichloroquinoxaline, 11.5 g. of 2-piperidinomethanol, 40 ml. of triethylamine and 400 ml. of dimethylformamide is stirred at room temperature for 4 hours and then heated on a steam bath for 48 hours. A 500 ml. portion of water is added dropwise. The solid is recovered by filtration, washed with water and air dried. This solid is dissolved in dichloromethane, passed through Magnesol and recrystallized from ethyl acetate. Recrystallization from ethanol or ethyl acetate gives pale yellow crystals of 10-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 147-149 C. Fractional crystallization from the mother liquor gives a second yield of the above 10-chloro derivative plus 9-chloro-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 107-109 C. The monohydrochloride salts of both compounds may be prepared as described in Example 1 and decompose above 300 C., 2958-87-4
2958-87-4 2,3,6-Trichloroquinoxaline 18070, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; American Cyanamid Company; US4200748; (1980); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider