With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
A 25-mL round bottom flask equipped with a magnetic stirrer,a condenser and a nitrogen in/outlet adapter was charged with2-bromoquinoxaline (13 mg, 0.063 mmol), 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-carbomethoxy-4?-(t-butyl)phenyl-[1,1?]biphenyl (25 mg, 0.063mmol), water/dioxane (1.0 mL/4.0 ml), K2CO3 (17 mg, 0.126mmol). The resulting solution wasdegassed for 15 min, then Pd(PPh3)4 (5 mg) wasadded. The reaction mixture was warmedto 100oC and stirred for 1 h.After cooled to room temperature, the reaction mixture was diluted withEtOAc and washed with saturated NaHCO3, brine, dried over Na2SO4.The organic layer was concentrated in rotavapor and purified on silicagel. Elution with 10 % EtOAc/hexanessolvent system afforded the desired compound (15 mg, 60 % yield) . 1HNMR (300 MHz, CDCl3) delta 9.46 (s, 1H), 8.83 (s, 1H), 8.69 (m, 1H),8.46 (s, 1H), 8.21 (m, 2H), 7.86 (m, 2H), 7.72 (d, J =12.0 Hz, 2H), 7.58 (d, J= 12.0 Hz, 2H), 4.05 (s, 3H), 1.42 (s, 9H).
36856-91-4, The synthetic route of 36856-91-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Parhi, Ajit K.; Zhang, Yongzheng; Saionz, Kurt W.; Pradhan, Padmanava; Kaul, Malvika; Trivedi, Kalkal; Pilch, Daniel S.; Lavoie, Edmond J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 17; (2013); p. 4968 – 4974;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider