With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6924-66-9,Quinoxaline-5-carboxylic acid,as a common compound, the synthetic route is as follows.
6924-66-9, Example 25To a 50 mL flask containing 20 mL of DMF was added 1 mL of oxalyi chloride slowly and stirred for 10 min at RT. 100 mg of quinoxaline-5-carboxyltc acid was dissolved in 2 mL of the above solution and stirred for 5 min at RT. Then 50 mg of E was dissolved in 1 mL pyridine and added to the above solution. The reaction was completed in 5 min at RT and quenched with 1 mL NH4OH. The solvent was then evaporated under vacuum and the residue dissolved in CH3CN and water and purified with prep HPLC (0% to 95% water/ Acetonitriie) to afford 25 (26.7 mg, 54%). 1H-NMR (DMSO, 300 MHz): delta 9.04-9.02 (m, 2H), 8.49 (d, J = 3.9 Hz, 1 H), 8.31 (d, J = 6.0 Hz, 1 H), 8.24 (d, J = 8.4 Hz, 1 H), 7.94 (t, J – 7.2 Hz, 1 H), 7.73 (d, J = 6.9 Hz, 1 H), 7.62-7.57 (m, 2H), 7.22 (t, J = 8.4 Hz, 1 H), 7.06 (t, J = 6.6 Hz, 1 H)1 6.98 (d, J = 7.8 Hz, 2H), 6.80 (d, J = 7.5 Hz, 1 H), 4.83 (me, 1 H), 3.18-3.06 (m, 3H), 2.77-2.75 (m, 1 H), 0.65 (m, 2H), 0.51 (m, 2H).LCMS m/z [M+Hj+ C32H25N5O3S requires: 560.64. Found 560.08 HPLC Tr (min), purity %: 3.36, 98%
6924-66-9 Quinoxaline-5-carboxylic acid 776833, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; GILEAD SCIENCES, INC.; MACKMAN, Richard, L.; SPERANDIO, David; YANG, Hai; WO2011/5842; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider