55687-02-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55687-02-0,6-Bromo-2-chloroquinoxaline,as a common compound, the synthetic route is as follows.
6-bromo, 2-chloroquinoxaline (0.35 g 1.4 mmol) was dissolved in DMSO (12 ml_) at room temperature and (R)-1-(3-Chloro-phenyl)-ethylamine (0.44 g, 2.8 mmol) was added. The reaction mixture was stirred at RT for 16 hours. After completion of the reaction (confirmed by TLC), water (10OmL) was added to the reaction mixture and it was extracted with ethyl acetate (50 mL x 3). The organic layer was washed with water (15 mL), brine (15 mL), and then dried over Na2SO4. The organic layer was concentrated in vacuo to afford the crude product.The crude product was adsorbed on 60-120 mesh silica gel and purified by column chromatography using neutral silica gel of 60-120 mesh size. A gradient of 0.5 % methanol in DCM was used for elution of the title compound (0.380 g, 72%).
As the paragraph descriping shows that 55687-02-0 is playing an increasingly important role.
Reference£º
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter; WO2010/136755; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider