6925-00-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6925-00-4,Quinoxaline-6-carboxylic acid,as a common compound, the synthetic route is as follows.
Method 3; tert-Butyl {4-methyl-3-r(quinoxalin-6-ylcarbonyl’)amino1phenyl>carbamate; A solution of tert-butyl (3-amino-4-methylphenyl)carbamate (Method 2; 50.10 g, 0.23 mol), quinoxaline-6-carboxylic acid (50.10 g, 0.23 mol) and diisoproplyethylamine (70 ml, 0.68 mol) in DMF (575 ml) was treated with HATU (94.3 g, 0.25 mol). The reaction was stirred at 25 0C for 24 h. The reaction was quenched with H2O and extracted with EtOAc. The organics were dried with NaCl (sat) and then Na2SO4 (s) and removed under reduced pressure. The resulting solid was recrystallized from DCM/hexanes affording the product as brown crystals; m/z 379.
As the paragraph descriping shows that 6925-00-4 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/40568; (2006); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider