3476-89-9, 1,2,3,4-Tetrahydroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of compound 14-1 (270 mg, 2 mmol) in THF (10 mL) was added LiAlH4 (0411) (228 mg, 6 mmol) at 0 C. The resulting mixture was stirred at 0 C for 30 min then stirred at room temperature overnight. The reaction was quenched with 0.25 mL H20, 0.25 mL 5N NaOH and 1.25 mL H20. The participate was filtered off, and the filtrate was extracted with EtOAc (3 x 20 mL). The organic layers were separated, washed with brine, dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 60% EtOAc/hexane) to obtain as light yellow solid (90 mg, 34%). To a stirred solution of the intermediate afforded in last step (90 mg, 0.67 mmol) in THF was added Boc20 (146 mg, 0.67 mmol) and aqueous solution NaOH (IN, 0.67 mL) at 0 C. Then the resulting mixture was stirred at room temperature overnight. The reaction was quenched with water, extracted with EtOAc (3 x 10 mL). The organic layers were separated, washed with brine, dried over sodium sulfate, and concentrated under vacuum. The crude product was purified by flash chromatography (0 – 60% EtOAc/hexanes) to obtain as light yellow oil (90 mg, 57%). 1H NMR (400 MHz, CDC13) delta 7.49 (d, / = 7.7 Hz, 1H), 6.89 (td, / = 8.0, 1.4 Hz, 1H), 6.69 – 6.60 (m, 1H), 6.55 (dd, / = 8.0, 1.3 Hz, 1H), 3.94 (s, 1H), 3.83 – 3.69 (m, 2H), 3.47 – 3.34 (m, 2H), 1.52 (s, 9H).
3476-89-9 1,2,3,4-Tetrahydroquinoxaline 77028, aquinoxaline compound, is more and more widely used in various.
Reference£º
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; SHEN, Sida; BERGMAN, Joel; (100 pag.)WO2017/142883; (2017); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider