6298-37-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6298-37-9,Quinoxalin-6-amine,as a common compound, the synthetic route is as follows.
A mixture of tert-butyl (4-nitrophenyl) butane-1,4-diyldicarbamate (3) (550 mg,1.55 mmol), quinoxalin-6-amine (339 mg,2.33 mmol), DMF (6.6 mL), and Et3N (0.43 mL, 3.11 mmol) in a 20 mL microwave vial washeated in a Biotage microwave at normal absorption for 2.75 h at 80 C. Solvent was removed invacuo. The crude product was purified on a silica cartridge (40 g) with a CombiflashCompanion, eluting at 35 mL/min with a gradient running from 100% DCM to 100 % EtOAcover 55 min to afford the free base tert-butyl (4-(3-(quinoxalin-6-yl)ureido)butyl)carbamate (334mg, 0.890 mmol, 60 % yield) LCMS (ES)+ [M+H]+ = 360.2 (0.78 min).
The synthetic route of 6298-37-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Boehm, Jeffrey; Davis, Roderick; Murar, Claudia E.; Li, Tindy; McCleland, Brent; Dong, Shuping; Yan, Hongxing; Kerns, Jeffrey; Moody, Christopher J.; Wilson, Anthony J.; Graves, Alan P.; Mentzer, Mary; Qi, Hongwei; Yonchuk, John; Kou, Jen-Pyng; Foley, Joseph; Sanchez, Yolanda; Podolin, Patricia L.; Bolognese, Brian; Booth-Genthe, Catherine; Galop, Marc; Wolfe, Lawrence; Carr, Robin; Callahan, James F.; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 579 – 588;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider