Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes.Safety of 8-Hydroxyquinoline 1-oxide.
Several ligands were designed to promote transition-metal-free cross-coupling reactions of aryl halides with benzene derivatives Among the systems probed, quinoline-1-amino-2-carboxylic acid was found to serve as an excellent catalyst for cross-coupling between aryl halides and unactivated benzene. Reactions using this inexpensive catalytic system displayed a high functional group tolerance as well as excellent chemoselectivities.
In addition to the literature in the link below, there is a lot of literature about this compound(8-Hydroxyquinoline 1-oxide)Safety of 8-Hydroxyquinoline 1-oxide, illustrating the importance and wide applicability of this compound(1127-45-3).
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider