With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.36856-91-4,2-Bromoquinoxaline,as a common compound, the synthetic route is as follows.
Under nitrogen protection,The diprazole pyrene intermediate 100 mmol,2-bromoquinoxaline 223 mmol,Tris (dibenzylideneacetone) dipalladium 5.0 mmol,Sodium tert-butoxide,Tri-tert-butylphosphine (20.1 mmol) was placed in a reaction vessel,And dissolved in 500 ml of toluene,110 reflux reaction 24h,The reaction end point was determined by thin layer chromatography (TLC)After completion of the reaction, the mixture was cooled to room temperature, passed through a silica gel funnel, washed with methylene chloride, spin dried, recrystallized from dichloromethane / petroleum ether,After drying, 81 mmol of compound 15 was obtained in 81% yield.
36856-91-4, As the paragraph descriping shows that 36856-91-4 is playing an increasingly important role.
Reference£º
Patent; Shanghai Keliente Chemical Materials Co., Ltd.; Yin Enxin; Lin Wenjing; (17 pag.)CN104262347; (2017); B;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider