The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists, the main research direction is dihydrotriazolopyrazinone P2X7 receptor antagonist SAR preparation; 6,7-Dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one; Autoradiography; CNS; Depression; P2X7.Electric Literature of C3H12Cl2N2.
The synthesis, SAR, and preclin. characterization of a series of substituted 6,7-dihydro[1,2,4]triazolo[4,3]pyrazin-8(5H)-one P2X7 receptor antagonists are described. Optimized leads from this series comprise some of the most potent human P2X7R antagonists reported to date (IC50s < 1 nM). They also exhibit sufficient potency and oral bioavailability in rat to enable extensive in vivo profiling. Although many of the disclosed compounds are peripherally restricted, compound I is brain penetrant and upon oral administration demonstrated dose-dependent target engagement in rat hippocampus as determined by ex vivo receptor occupancy with radiotracer II (ED50 = 0.8 mg/kg). Compounds in my other articles are similar to this one((S)-Propane-1,2-diamine dihydrochloride)Electric Literature of C3H12Cl2N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider