Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues. Author is Mei, Tie-Wen; Luo, Yu; Feng, Xiang-Jun; Lu, Wei; Yang, Bo.
A concise synthesis of Fingolimod (FTY720) and its analogs was described. The key step involved Suzuki coupling of aryl boronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogs were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.
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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider