Hsu, Fu-Lian; Hamada, Akihiko; Booher, Mark E.; Fuder, H.; Patil, P. N.; Miller, Duane D. published the article 《Optically active derivatives of imidazolines. α-Adrenergic blocking properties》. Keywords: imidazoline stereoisomer preparation adrenergic blocker.They researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Computed Properties of C3H12Cl2N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:19777-66-3) here.
The title compounds I (R and R1 = H, Me, or PhCH2; R2 = 1-naphthylmethyl, PhCH2, or 2,6-dichloroaniline) as salts were prepared from an optically active 1,2-diamine-2HCl and an imino ester HCl, and converted to a stable solid salt. I were evaluated for α-adrenergic activity on rabbit aortic strips. Compared to naphazoline or tolazoline, substitution of a Me or PhCH2 at the 4 position of the imidazoline ring resulted in moderate α-blocking activity with no apparent stereoselectivity with such substitution.
Although many compounds look similar to this compound(19777-66-3)Computed Properties of C3H12Cl2N2, numerous studies have shown that this compound(SMILES:C[C@H](N)CN.[H]Cl.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider