Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Bromo-5-phenyloxazole, is researched, Molecular C9H6BrNO, CAS is 740806-67-1, about Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping.SDS of cas: 740806-67-1.
Oxazoles were rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethyl isocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonattion of Asmic afforded a metalated isocyanide that efficiently trapped esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent was readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility was illustrated in the three-step synthesis of the bioactive natural product streptochlorin.
After consulting a lot of data, we found that this compound(740806-67-1)SDS of cas: 740806-67-1 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider