With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.
49679-45-0, General procedure: To ethyl 3-chloroquinoxaline-2-carboxylate 1 (1 g, 4.22 mmol),appropriate acetylene derivative (3.33 mmol, 1.5 eq.) in ethanol(15 mL) was added in a two-necked flask containing triethylamine(1.4 mL, 10 mmol), Pd/C (45 mg, 0.42 mmol), triphenylphosphine(110 mg, 0.42 mmol), and CuI (50 mg, 0.26 mmol). The reaction mixture was stirred at 60 C for 5 h. After cooling, the mixture wasfiltered with celite and the filtrate diluted with dichloromethane,washed with H2O (3 x 40 mL) and dried over MgSO4. After evaporation,the crude product was purified by silica gel chromatography(CH2Cl2). 4.1.1.1. Ethyl 3-(phenylethynyl)quinoxaline-2-carboxylate (2a) Yellowsolid; mp 109 C. 1H NMR (200 MHz, CDCl3) = delta (ppm) 1.48 (t,J = 7.1 Hz, 3H), 4.60 (q, J = 7.1 Hz, 2H), 7.37-7.43 (m, 3H), 7.66-7.69(m, 2H), 7.77-7.88 (m, 2H), 8.11-8.20 (m, 2H). 13C NMR (50 MHz,CDCl3) = delta (ppm) 14.2, 62.6, 86.1, 96.0, 121.5, 128.4 (3), 128.8, 129.7(2), 131.1, 132.2, 132.3, 137.2,139.3, 142.3, 146.1, 164.4. Anal. Calcd forC19H14N2O2: C, 75.48; H, 4.67; N, 9.27. Found: C, 75.71; H, 4.52; N,9.21.
49679-45-0 Ethyl 3-chloroquinoxaline-2-carboxylate 12283436, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Hajri, Majdi; Esteve, Marie-Anne; Khoumeri, Omar; Abderrahim, Raoudha; Terme, Thierry; Montana, Marc; Vanelle, Patrice; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 959 – 966;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider