1,2-Ethylenediols of quinoxaline and 1-phenyl-pyrazolo[o,4-b]quinoxaline was written by Binte, Hans J.;Henseke, Guenter;Bauer, Werner;Koehnke, Kurt. And the article was included in Zeitschrift fuer Chemie in 1968.Application of 5448-43-1 This article mentions the following:
Quinoxaloin (I) was acylated with Ac2O in pyridine to the diacetate, m. 232°, and with BzCl to the dibenzoate, m. 240°. Quinoxaloin diacetate was also obtained directly from quinoxaline-2-carboxaldehyde with Ac2O in pyridine at room temperature I was dehydrated by treatment with air in HCONMe2 to give quinoxalil, m. 248°. Oxidation of I with concentrated HNO3 gave quinoxaline-2-carboxylic acid, m. 212°. Quinoxalil condensed with o-H2NC6H4NH2 in CHCl3 to give 2,3-di(2-quinoxalyl)quinoxaline, m. 231°. R-substituted-quinoxaline-2-carboxaldehydes (II) reacted with KCN in 60% EtOH to give the following R-substituted quinoxaloins (R and m.p. given): 6- or 7-NO2, 297°; 6- or 7-Cl, 290-2°; 6-Cl, 295°; 7-Cl, 292°. II were prepared by HIO4 cleavage of the corresponding R-substituted 2-(D-arabino-tetrahydroxybutyl)quinoxaline. II (R = 6-Cl) formed a yellow phenylhydrazone, m. 197°, while II (R = 6- or 7-NO2) formed a red phenylhydrazone, m. 220-2°. 6(7)-Chloroquinoxaloin gave 6(7), 6′(7)-dichloroquinoxalyl, m. 321-3°, on oxidation with air and 6(7)-chloroquinoxaline-2-carboxylic acid, m. 241°, with HNO3. 7,7′-Dichloro-1,1′-diphenylflavazoin (III), m. 275°, was also prepared; diacetate m. 335-40°; dibenzoate m. 355-60°. It is also dehydrated with air to give isomeric flavazils, m. 300 and 334°. 1,1′-Diphenylflavazoin formed a bis(phenylhydrazone), m. 160°, while the flavazil (m. 300°) formed a monophenylhydrazone, m. 195-8°. The flavazil (m. 300°) reacted with o-H2NC6H4NH2 to give 2,3-bis(1-phenylpyrazolo[3,4-b]quinoxal-3-yl)quinoxaline, m. 283°. Tollens reagent is slowly reduced by I, II, and 1,1′-diphenylflavazoin, while Tillman reagent is reduced almost instantly in acid medium, but not in alk. medium. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Application of 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Application of 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider