Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties was written by Lassagne, Frederic;Sims, Joshua M.;Erb, William;Mongin, Olivier;Richy, Nicolas;El Osmani, Nour;Fajloun, Ziad;Picot, Laurent;Thiery, Valerie;Robert, Thomas;Bach, Stephane;Dorcet, Vincent;Roisnel, Thierry;Mongin, Florence. And the article was included in European Journal of Organic Chemistry in 2021.Name: 3-Chloroquinoxalin-6-amine This article mentions the following:
The regioselective iodination of different 2-mono-, 3-mono- and 2,3-disubstituted 6-aminoquinoxalines, which took place at their 5-position, was rationalized on the basis of Hueckel theory calculations Oxazolo- and thiazolo[5,4-f]quinoxaline analogs of reported disease-related protein kinases inhibitors were synthesized from the obtained 6-amino-5-iodoquinoxalines by using as key step copper-catalyzed azole ring formation. Pyrazino[b,e]isatins were obtained, for the first time, from the same substrates by recourse to Sonogashira coupling, alkyne hydration, and oxidative cyclization. The absorption and emission properties of the most promising compounds were recorded. In addition, most of the synthesized polycycles were evaluated as protein kinase inhibitors and for their antiproliferative activity towards cancer cells. In the experiment, the researchers used many compounds, for example, 3-Chloroquinoxalin-6-amine (cas: 166402-16-0Name: 3-Chloroquinoxalin-6-amine).
3-Chloroquinoxalin-6-amine (cas: 166402-16-0) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Name: 3-Chloroquinoxalin-6-amine
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider