Novel rhodamine dye with large Stokes shifts by fusing the 1,4-diethylpiperazine moiety and its applications in fast detection of Cu2+ was written by Gong, Jin;Liu, Chang;Jiao, Xiaojie;He, Song;Zhao, Liancheng;Zeng, Xianshun. And the article was included in RSC Advances in 2020.SDS of cas: 6639-82-3 This article mentions the following:
Rhodamine dyes were widely developed for designing probes due to their excellent photophys. properties and biocompatibility. However, traditional rhodamine dyes still bear major drawbacks of short emission wavelengths (<600 nm) and narrow Stokes shifts (<30 nm), which limit their biol. imaging applications. Herein, the authors reported a novel mitochondria-targeted fluorescent dye JRQ with near-IR (NIR) emission wavelength and improved Stokes shift (63 nm) by tuning the donor-acceptor-donor (D-A-D) character of the rhodamine skeleton. As expected, JRQ exhibited multiple excellent properties and could accumulate in mitochondria, and can therefore be used as a signal reporter for the design of fluorescent probes by taking advantage of the fluorescence controlled mechanism of the ring opening and closing chem. processes of the spirolactone platform. By using JRQ as a precursor, a highly sensitive fluorescent probe JRQN for the fast detection of mitochondrial Cu2+ ions was synthesized based on the Cu2+-triggered specific hydrolysis mechanism because mitochondria are an important reservoir of intracellular Cu2+. The authors expect that the Stokes shift increase of rhodamine dyes via tuning the donor-acceptor-donor (D-A-D) character of the rhodamine skeleton will provide a novel synthetic approach for the development of rhodamine dyes and expansion of their applications. In the experiment, the researchers used many compounds, for example, 6-Methoxyquinoxaline (cas: 6639-82-3SDS of cas: 6639-82-3).
6-Methoxyquinoxaline (cas: 6639-82-3) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.SDS of cas: 6639-82-3
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider