The Nitration of 5-Methylquinoxalines in Mixed Acid was written by Marterer, Wolfgang;Prikoszovich, Walter;Wiss, Jacques;Prashad, Mahavir. And the article was included in Organic Process Research & Development in 2003.HPLC of Formula: 532934-95-5 This article mentions the following:
5-Methylquinoxalines are nitrated surprisingly efficiently at the 8 position following a simple nitration protocol with mixed acid at 40-50°. The implications of halogen functionalization at C-7 and modification of the mixed acid conditions on the relative rates of conversion and process safety are discussed. Competing side reactions for 7-halo-5-methylquinoxalines involve hydrolysis at C-7 and halogenation at C-6 or C-8. In the experiment, the researchers used many compounds, for example, 7-Bromo-5-methylquinoxaline (cas: 532934-95-5HPLC of Formula: 532934-95-5).
7-Bromo-5-methylquinoxaline (cas: 532934-95-5) belongs to quinoxaline derivatives. Compounds possessing quinoxaline derivatives were bestowed with a variety of significant biological properties such as antiviral, antimalarial, anticancer, DNA intercalation, DNA duplex stabilization, and many others. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.HPLC of Formula: 532934-95-5
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider