Prodrug Approach toward the Development of a PET Radioligand for Imaging the GluN2A Subunits of the NMDA Receptor was written by Gruber, Stefan;Waser, Valerie;Thiel, Zacharias;Ametamey, Simon M.. And the article was included in Organic Letters in 2021.Reference of 532934-95-5 This article mentions the following:
A straightforward synthesis of a F-18-labeled prodrug of AFA233 is reported. The key step in the preparation of [18F]AFA233-prodrug is the selective deprotection of the tert-Bu protection groups of the quinoxalinedione moiety without cleavage of the tert-butyl-S-acyl-2-thioethyl protection groups on the phosphate esters. The preparation of the nonradioactive prodrug reference compound of AFA233 is reported. In the experiment, the researchers used many compounds, for example, 7-Bromo-5-methylquinoxaline (cas: 532934-95-5Reference of 532934-95-5).
7-Bromo-5-methylquinoxaline (cas: 532934-95-5) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Reference of 532934-95-5
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider