Fordham, James M. et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 5448-43-1

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 5448-43-1

A “Pool and Split” Approach to the Optimization of Challenging Pd-Catalyzed C-N Cross-Coupling Reactions was written by Fordham, James M.;Kollmus, Philipp;Cavegn, Monika;Schneider, Regina;Santagostino, Marco. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 5448-43-1 This article mentions the following:

A screening method for the rapid identification of catalytic conditions for Pd-catalyzed C-N cross-coupling reactions was reported. The strategy evaluates mixtures of precatalysts, ligands and bases to identify productive conditions that are subsequently optimized through two deconvolution steps, which uncover the active catalyst and identify the optimal solvent and base for the catalytic system. The efficacy of this approach was demonstrated through application to a previously reported reaction, whereby both the literature conditions and addnl. solutions were retrieved. The same approach to Ni-catalyzed C-N cross-coupling was investigated in parallel but was found to be less successful due to limited activity of the evaluated reagent combinations. Finally, the utility of this method was showcased by identifying effective conditions for the Pd-catalyzed cross-coupling of complex mols., which not only revealed nonobvious solutions for the processes under evaluation, but also resulted in the discovery of new chem. reactions. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Product Details of 5448-43-1).

6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Product Details of 5448-43-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider