With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41959-35-7,6-Nitro-1,2,3,4-tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.
To a stirred solution of 789 6-nitro-1,2,3,4-tetrahydroquinoxaline (0.5 g, 2.79 mmol, 1.0 eq) in 743 DCM (20 mL) was added 155 triethylamine (1.17 mL, 8.37 mmol, 3.0 eq) and 790 DMAP (68 mg, 0.558 mmol, 0.2 eq) at rt. The resulting mixture was allowed to cool to 0 C. followed by addition of 482 di-tert-butyl dicarbonate (1.41 mL, 6.139 mmol, 2.2 eq), the reaction mixture was stirred at RT for overnight. The progress of reaction was monitored by LCMS. The reaction mixture was diluted with DCM (50 mL), and washed with water (2¡Á50 mL) dried over Na2SO4, filtered and concentrated and purified by combi flash [silica gel 100-200 mesh; elution 0-35% 19 EtOAc in 20 Hexane] to afford the desired compound 791 di-tert-butyl 6-nitro-2,3-dihydroquinoxaline-1,4-dicarboxylate (0.65 g, 61.43%) as yellow viscous. (0776) LCMS: (M+1)+380.4., 41959-35-7
41959-35-7 6-Nitro-1,2,3,4-tetrahydroquinoxaline 10197942, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider