6925-00-4, Quinoxaline-6-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6925-00-4
Example 5. 3,7-bis[(quinoxalin-6-yl)carbonyl]-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one (compound 5 corresponding to general formula 1.3).; To a solution of 34.8 g (0.2 mole) of quinoxaline-6-carboxylic acid in absolute dimethylformamide, 35.64 g (0.22 mole) of CDI were added while stirring and cooling in an ice bath. Stirring was carried out for five hours. Then a solution of 24.1 g (0.1 mole) of 1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one hydrochloride in DBU (1,8-diazabicyclo[5.4.0]undene-7) was added to the reaction mixture. The reaction was heated up to 50C and heated for eight hours. Then precipitate was filtered off. Filtrate was evaporated to dryness. The residue was applied on a chromatographic silica gel column. Chlorophorm was used as an eluent. A fraction with Rf=0.52 was recovered on silufol in the CHCl3-EtOH (20:1) system. Solvent was distilled off, and a clear oil was obtained which over time was crystallized. Yield: 64%. 1HNMR (CDCl3 delta, ppm): 0.97 s(6H); 3.00 d (2H, J 12 Hz); 3.34 d(2H, J 12 Hz); 4.22 d (2H, J 12 Hz); 4.84 d (2H, J 12 Hz); aromatic protons [7.80 d (1H, J=5.8 Hz), 8.18 s (1H), 8.20 d (1H, J=5.8 Hz)].
The synthetic route of 6925-00-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute of Physiologically active compunds of the Russian Academy of Sciences (IPAC RAN); EP2088149; (2009); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider