Metal-free regioselective nitration of quinoxalin-2(1H)-ones with tert-butyl nitrite was written by Li, Yi-Na;Li, Xue-Lin;Wu, Jin-Bo;Jiang, Hong;Liu, Yunmei;Guo, Yu;Zeng, Yao-Fu;Wang, Zhen. And the article was included in Organic & Biomolecular Chemistry in 2021.Synthetic Route of C8H6N2O This article mentions the following:
A metal-free coupling of quinoxalin-2(1H)-ones with tert-Bu nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the Ph ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Synthetic Route of C8H6N2O).
2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Synthetic Route of C8H6N2O
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider