With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.49679-45-0,Ethyl 3-chloroquinoxaline-2-carboxylate,as a common compound, the synthetic route is as follows.
(1) To a solution of ethyl 3-chloroquinoxaline-2-carboxylate (2.00 g, 8.41 mmol) was added sodium methoxide (28% in methanol, 3.60 g, 18.7 mmol) at 0 C. After being stirred for 1 hour at room temperature, the reaction mixture was diluted with dichloromethane (200 mL). The solution was neutralized with ammonium chloride and filtrated through celite. The filtrate was combined and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1 to 3:2), followed by trituration with hexane to give ethyl 3-methoxyquinoxaline-2-carboxylate as colorless powder (1.37 g, 74%). MS (APCI): m/z 219 (M+H).
49679-45-0, The synthetic route of 49679-45-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kawanishi, Eiji; Matsumura, Takehiko; US2011/160206; (2011); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider