Category: 108229-82-9

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 108229-82-9, In a patent£¬Which mentioned a new discovery about 108229-82-9

Pyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines and pyrrolo[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines

This disclosure describes substituted 2,3,3a,4-tetrahydro-1H-pyrrolo[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines and 1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxalines which possess anxioyltic activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N1994 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in DMF (50 mL), 4-(trifluoromethyl)aniline (1.61 g, 0.01 mol) was added. The reaction mixture was refluxed for 24 h. After completion of the reaction, the reaction mixture was poured onto crushed ice with stirring. Then, the solid residue that formed was filtered, washed with water, dried and crystallized from petroleum ether (80-100C) to give 4. Yield: 40%; (brown powder): m.p. 157-159 O C;IR (KBr, cm -1 ): 3158 (NH), 1603 (C=N). 1 H NMR(DMSO-d 6 , delta , ppm): 7.25-7.82 (m, 7H, Ar-H), 9.71(s, br, 1H, NH; exchangeable with D 2 O). 13 C NMR(DMSO-d 6 , delta , ppm): 121.15-147.09 (12Ar-C, CF 3 ),152.69, 152.86 (2C=N). MS (m/z), 336 (M + -C 2 H 3 F 2 ; 100%), 401 (M + ; 88%), 402 (M + + 1; 60%),403 (M + + 2; 57%), 404 (M + + 3; 62%), 405 (M + + 4;52%). Analysis: calcd. for C 15 H 8 BrClF 3 N 3 (402.60):C, 44.75; H, 2.00; N, 10.44%; found: C, 44.61; H,2.26; N, 10.69%.

108229-82-9, 108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 1 (2.78 g, 0.01 mol) in acetic acid (50 mL), o-phenylenediamine (1.62 g,0.015 mol) was added and the reaction mixture was refluxed for 7 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried, crystallized fromethanol and purified by column chromatography using an elution system chloroform : methanol (10 :0.3, v/v) to give the product. Yield: 77%; (yellow powder): m.p. over 300C; IR (KBr, cm -1 ): 3182, 3112 (2NH), 1605 (C=N).1 H NMR (DMSO-d 6 , delta , ppm): 7.30-7.96 (m, 7H, Ar-H), 11.63, 11.70 (2s, br, 2H, 2NH; exchangeablewith D 2 O). 13 C NMR (DMSO-d 6 , delta , ppm): 114.43-143.23 (12Ar-C), 144.88, 145.03 (2C=N). MS(m/z), 312 (M + ; 100%), 313 (M + + 1; 23%), 314 (M ++ 2; 99.9%). Analysis: calcd. for C 14 H 9 BrN 4(313.15): C, 53.70; H, 2.90; N, 17.89%; found: C,53.92; H, 2.79; N, 18.04%., 108229-82-9

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of compound 1 (2.78 g, 0.01 mol)and 2-mercaptobenzimidazole (1.80 g, 0.012 mol) inabsolute ethanol (50 mL) was refluxed for 14 h.After completion of the reaction, the reaction mix-ture was cooled and the precipitate that formed wasfiltered, dried and crystallized from ethanol to givethe product. Yield: 44%; (gray powder): m.p. 229-231 O C;IR (KBr, cm -1 ): 1624 (C=N). 1 H NMR (DMSO-d 6 , delta ,ppm): 7.41-8.06 (m, 7H, Ar-H). 13 C NMR (DMSO-d 6 , delta , ppm): 114.40-140.97 (12Ar-C), 143.72, 152.90(3C=N). MS (m/z), 354 (M + ; 20%), 355 (M + + 1;100%), 356 (M + + 2; 23%). Analysis: calcd. forC 15 H 7 BrN 4 S (355.21): C, 50.72; H, 1.99; N, 15.77; S,9.03%; found: C, 50.91; H, 2.19; N, 15.65; S, 9.20%., 108229-82-9

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9 6-Bromo-2,3-dichloroquinoxaline 13799585, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108229-82-9,6-Bromo-2,3-dichloroquinoxaline,as a common compound, the synthetic route is as follows.

108229-82-9, To a solution of compound 1 (0.28 g, 1 mmol) in absolute ethanol (50 mL), hydrazine hydrate90% (0.07 mL, 1.5 mmol) was added and the reaction mixture was stirred in an ice bath at 0 C for 2 h.After completion of the reaction, the precipitate that formed was filtered, dried and the crude productwas further purified by a silica gel column chromatography (chloroform) to give the product. Yield:61%; (red-brown powder): mp 201-203 C; IR (KBr) max in cm1: 3415, 3250, 3146 (NH2, NH), 1598(C=N); 1H-NMR (DMSO-d6): 5.00 (s, br, 2H, NH2; exchangeable with D2O), 7.37-7.79 (m, 3H, Ar-H),9.16 (s, br, 1H, NH; exchangeable with D2O); 13C-NMR (DMSO-d6): 124.68, 129.67, 130.02, 134.78,138.98, 140.60 (6Ar-C), 145.22, 145.85, (2C=N); MS (m/z), 64 (M+ C4H4BrClN3; 100%), 272 (M+; 5%),273 (M+ + 1; 21%), 274 (M+ + 2; 17%), 275 (M+ + 3; 3%), 276 (M+ + 4; 5%). Anal. Calcd. for C8H6BrClN4(273.52): C, 35.13; H, 2.21; N, 20.48%. Found: C, 34.97; H, 2.45; N, 20.34%.

The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Marhabi, Aisha R.; Abbas, Hebat-Allah S.; Ammar, Yousry A.; Molecules; vol. 20; 11; (2015); p. 19805 – 19822;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 16 9-Bromo-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline and 10-bromo-1,2,3,4,4a,5-hexahydropyrido[1′,2′:4,5][1,4]oxazino[2,3-b]quinoxaline The above compounds are obtained when 6-bromo-2,3-dichloro quinoxaline is treated with 2-piperidinomethanol by the procedure of Example 2.

108229-82-9, The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; American Cyanamid Company; US4200748; (1980); A;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 1 (2.78 g, 0.01 mol) in acetonitrile (50 mL), anhydrous potassium carbonate (2.0 g) and an appropriate cyclic secondaryamine namely, piperidine or morpholine (0.01 mol) was added. The reaction mixture was refluxed for 4-h. After completion of the reaction, the reaction mixture was filtered to remove the potassium carbonate, then the excess of acetonitrile was evaporated under reduced pressure and the residue obtained was dried and crystallized from petroleum ether (60-80C) to afford the corresponding compounds.

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Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Sodium hydride (349 mg, 0.008792 mol, 1.2 eq) was added to a solution of 2-ethylbutyl 2-cyanoacetate (1.23 g, 0.007326 mol, 1.00 eq) in dry DMF (20 ml) at 0C under inert atmosphere. After 10 minutes, 2,3-dichloroquinoxaline (1.75 g, 0.008792 mol, 1.2 eq) was added and the reacting mixture was stirred overnight at 70C. The solution was cooled to 0C then diluted in sat. H4CI and extracted with DCM . The combined organic layers were dried over MgS0 , filtered and concentrated. Purification by column chromatography on silica gel (0 to 30% AcOEi/liexanes) provided 2-ethylbutyi 2-(3-chloroquinoxalin-2-yl)-2-cyanoacetate as a yellow solid (2.20 g, 74% yield). A solution of (Z)-2-ethylbutyl 2-(3-chloroquinoxalin-2(lH)-ylidene)-2-cyanoacetate (1 eq), piperazine (3 eq) and DIPEA (3 eq) in methanol (0.1M) was stirred at 120C in a microwave for 90 minutes or until completion. The solution was cooled down, diluted in water/DCM followed by extraction with DCM. The combined organic layers were dried over MgS04, filtered, concentrated and purified by column chromatography on silica gel (0 to 100% AcOEt in hexanes) or by reverse phase C18 (5 to 100% CH3CN 0.1% TFA in water 0.1% TFA) to furnish (Z)-2-ethylbutyl 2-cyano-2-(3-(piperazin-l-yl)quinoxalin-2(lH)-ylidene)acetate., 108229-82-9

As the paragraph descriping shows that 108229-82-9 is playing an increasingly important role.

Reference£º
Patent; CORSELLO, Steven M.; GOLUB, Todd R.; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; STEFAN, Eric; HILGRAF, Robert; (158 pag.)WO2018/183936; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

108229-82-9, 6-Bromo-2,3-dichloroquinoxaline is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of compound 1 (2.78 g, 0.01 mol)and arylthiosemicarbazone (0.01 mol) in absolute ethanol (50 mL) was refluxed for 4-5 h. After completion of the reaction, the reaction mixture was cooled and the precipitate that formed was filtered, dried and crystallized from benzene to produce the corresponding compounds.

108229-82-9, The synthetic route of 108229-82-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abbas, Hebat-Allah S.; Al-Marhabi, Aisha R. M.; Ammar, Yousry A.; Acta poloniae pharmaceutica; vol. 74; 2; (2017); p. 445 – 458;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider