Category: 1127-45-3

Al-Zagoum, M. N.; Warren, C. G. published the article 《Acid reaction and ionization constants of 8-hydroxyquinoline-N-oxide》. Keywords: oxine N oxide property; acid property oxine N oxide; hydroxyquinoline N oxide; dissociation oxine N oxide.They researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Recommanded Product: 1127-45-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1127-45-3) here.

The constants for the acid reactions of 8-hydroxyquinoline-N-oxide were determined at 25° and M ionic strength. The 1st ionization constant for the cation of oxine-N-oxide, H2Q+, was 0.0486 ± 0.0004. The constant for the acid reaction for the 2nd ionization of the above compound was 176 kw ± 15, where kw is the ion product of water. This constant is for the ionization of oxine-N-oxide which produces H ions and a combination of basic forms including the anion and the Na salt. The 1st ionization constant was determined by potentiometric measurements. The 2nd ionization was studied by solvent extraction methods. The reagent was synthesized by a modified K. Ramaiah and V. R. Srinivasan (1962) procedure.

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Computed Properties of C9H7NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Synthesis of 2-Alkenylquinoline by Reductive Olefination of Quinoline N-Oxide under Metal-Free Conditions. Author is Xia, Hong; Liu, Yuanhong; Zhao, Peng; Gou, Shaohua; Wang, Jun.

Synthesis of 2-alkenylquinoline by reductive olefination of quinoline N-oxide under metal-free conditions is disclosed. Practically, the reaction could be performed with quinoline as starting material via a one-pot, two-step process. A possible mechanism is proposed that involves a sequential 1,3-dipolar cycloaddition and acid-assisted ring opening followed by a dehydration process.

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HPLC of Formula: 1127-45-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Natural abundance oxygen-17 NMR spectroscopy of heterocyclic N-oxides and di-N-oxides. Structural effects.

The 17O chem. shift data for a series of azine N-oxides, diazine N-oxides and di-N-oxides at natural abundance are reported. Isomeric Me substituted quinoline N-oxides exhibited chem. shifts which are interpreted in terms of electronic and compressional effects. The 17O chem. shift for 8-methylquinoline N-oxide (370 ppm) is deshielded by 25 ppm more than predicted, based upon electronic considerations. The 17O chem. shift for the N-oxide of 8-hydroxyquinoline (289 ppm) is substantially shielded as a result of intramol. hydrogen bonding. The relative 17O chem. shifts for diazine N-oxides of pyrazine, pyridazine and pyrimidine follow predictions based on back donation considerations. Because of solubility limitations, spectra of only 2 N,N’-dioxides were obtained. The chem. shift of benzopyrazine di-N-oxide in acetonitrile was shielded by 18 ppm compared to that of its mono N-oxide.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Hydroxyquinoline 1-oxide(SMILESS: OC1=CC=CC2=CC=C[N+]([O-])=C12,cas:1127-45-3) is researched.Formula: C9H11Br. The article 《Azo compounds from 8-hydroxyguinoline N-oxide and its analogs as a new class of organic reagents》 in relation to this compound, is published in Org. Reagenty Anal. Khim., Tezisy Dokl. Vses. Konf., 4th. Let’s take a look at the latest research on this compound (cas:1127-45-3).

Reagents for photometric and extraction-photometric determination of Co, Cu, Ni, Pd, Ag, and other metals were prepared by coupling benzenediazonium or its derivatives and 8-quinolinol N-oxide (I) and its derivatives Cu2+ was determined by extraction of its complex with the coupling product of diazotized picramic acid and I into CHCl3 from a pH 6-7 solution and measuring the absorbance. The same reagent was used for determining Pd phtometrically at pH 0.5-8. The complexes of metals other than Cu were not extractable.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1127-45-3, is researched, Molecular C9H7NO2, about Identification of the Aromatic Tertiary N-Oxide Functionality in Protonated Analytes via Ion/Molecule Reactions in Mass Spectrometers, the main research direction is aromatic tertiary amine oxide identification ion mol reaction methoxypropene.Synthetic Route of C9H7NO2.

A mass spectrometric method is presented for the rapid identification of compounds that contain the aromatic N-oxide functional group. This method utilizes a gas-phase ion/mol. reaction with 2-methoxypropene that yields a stable adduct for protonated aromatic tertiary N-oxides (and with one protonated nitrone) in different mass spectrometers. A variety of protonated analytes with O- or N-containing functional groups were examined to probe the selectivity of the reaction. Besides protonated aromatic tertiary N-oxides and one nitrone, only three protonated amines were found to form a stable adduct but very slowly. All the other protonated analytes, including aliphatic tertiary N-oxides, primary N-oxides, and secondary N-oxides, are unreactive toward or react predominantly by proton transfer with 2-methoxypropene.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectrophotometric studies of iron(III)-8-quinolinol N-oxide complex》. Authors are Bhat, A. N.; Jain, B. D..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).HPLC of Formula: 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

Spectrophotometric data at 30° from continuous variations and slope ratio methods show a 1:1 molar ratio of Fe to 8-quinolinol N-oxide in a pH range of 0.5-3.5, contrary to a 1:3 ratio reported by Murase (CA 49, 10786d). The complex was brownish green. Stability constant determination by the 2 methods gave log K = 3.28 and 3.63, resp. The absorption maximum was 510 mμ. In pH range 6.5-8.4, maximum was at 425-30 mμ, and in pH range 3.6-6.0, maximum were at 510 and 430 mμ; this indicates a mixture at pH 3.6-6.0.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1127-45-3, is researched, Molecular C9H7NO2, about Magnetic study of a one-dimensional Mn(II) coordination polymer dealing with π-π stacking, the main research direction is manganese pyrazinedioxide hydroxylquinoline oxide polymeric complex preparation structure; crystal structure manganese pyrazinedioxide hydroxylquinoline oxide polymeric complex; antiferromagnetic exchange manganese pyrazinedioxide hydroxylquinoline oxide polymeric complex; ferromagnetic exchange manganese pyrazinedioxide hydroxylquinoline oxide polymeric complex; electronic structure manganese pyrazinedioxide hydroxylquinoline oxide polymeric complex.SDS of cas: 1127-45-3.

A new one-dimensional chain manganese(II) coordination polymer, {[Mn(μ-Dpd)(Q)2(H2O)2]2(ClO4)}n (Dpd = 2,5-dimethylpyrazine-1,4-dioxide; Q = 8-hydroxylquinoline N-oxide), was synthesized with 2,5-dimethylpyrazine-1,4-dioxide as bridge ligand and 8-hydroxylquinoline N-oxide as terminal ligand, and its crystal structure determined by X-ray crystallog. The structure anal. indicates that there are two pathways for magnetic interactions: one is through bridge ligand 2,5-dimethylpyrazine-1,4-dioxide, and another is by π-π stacking of adjacent quinoline rings. The theor. calculations reveal that there exist a anti-ferromagnetic interaction from spin delocalization and a ferromagnetic interaction from spin polarization for 2,5-dimethylpyrazine-1,4-dioxide bridge pathway, but the anti-ferromagnetic interaction is stronger than the ferromagnetic interaction leading to an anti-ferromagnetic interaction with J = -2.53 cm-1, whereas for the π-π stacking pathway it resulted in a ferromagnetic interaction with J = 0.013 cm-1. The exptl. fitting on the data of the variable temperature magnetic susceptibilities gave the magnetic interaction constant J = 0.07 cm-1, which is similar with the results of the theor. calculations

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yang, Kai; Qiu, Yatao; Li, Zheng; Wang, Zhaoyang; Jiang, Sheng researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Name: 8-Hydroxyquinoline 1-oxide.They published the article 《Ligands for Copper-Catalyzed C-N Bond Forming Reactions with 1 Mol% CuBr as Catalyst》 about this compound( cas:1127-45-3 ) in Journal of Organic Chemistry. Keywords: aryl halide amine hydroxyquinoline oxide copper Ullman coupling; arylamine preparation; Ullman coupling catalyst hydroxyquinolinoxide copper. We’ll tell you more about this compound (cas:1127-45-3).

Several new ligands were designed to promote copper-catalyzed Ullman C-N coupling reactions. In this group, 8-hydroxyquinoline-N-oxide was found to serve as a superior ligand for CuBr-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-heterocycles under a low catalyst loading (1% [Cu] mol). Reactions with the inexpensive catalytic system display a high functional group tolerance as well as excellent chemoselectivity.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1127-45-3, is researched, Molecular C9H7NO2, about Hydrogen bonds in quinoline N-oxide derivatives: first-principle molecular dynamics and metadynamics ground state study, the main research direction is hydrogen bonds quinoline oxide derivatives free energy surface; free energy surface proton motion reproduced unconstrained CPMD.Computed Properties of C9H7NO2.

Car-Parrinello mol. dynamics simulations were carried out for 8-hydroxyquinoline N-oxide (1) and 2-carboxyquinoline N-oxide (2) in vacuo and in the solid state. The first-principle approach was employed to intramol. hydrogen bond features present in the studied quinoline N-oxides. Grimme’s dispersion correction was employed throughout the study. Special attention was devoted to the solid-state computations knowing that in the mol. crystals, strong and weak interactions are responsible for spatial organization and mol. properties of mols. On the basis of Car-Parrinello mol. dynamics, it was possible to reproduce the hydrogen bond dynamics as well as to investigate the vibrational features on the basis of Fourier transform of the at. velocity autocorrelation function. The free energy surfaces for proton motion were reproduced by unconstrained CPMD runs as well as by metadynamics. Larger flexibility of the bridge proton in 2 was noticed. The computations are verified by exptl. X-ray and IR data available.

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COA of Formula: C9H7NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about High anticancer activity and apoptosis- and autophagy-inducing properties of novel lanthanide(III) complexes bearing 8-hydroxyquinoline-N-oxide and 1,10-phenanthroline. Author is Yang, Yan; Zhou, Zhen; Wei, Zu-Zhuang; Qin, Qi-Pin; Yang, Lin; Liang, Hong.

In the quest for rare earth metal complexes with enhanced cancer chemotherapeutic properties, the discovery of seven lanthanide(III) complexes bearing 8-hydroxyquinoline-N-oxide (NQ) and 1,10-phenanthroline (phen) ligands as potential anticancer drugs is described. Complexes [SmIII(NQ)(phen)(H2O)Cl2] , [EuII(NQ)(phen)(H2O)Cl2] , [GdIII(NQ)(phen)(H2O)Cl2] , [DyIII(NQ)(phen)(H2O)Cl2] , [HoIII(NQ)(phen)(H2O)Cl2] , [ErIII(NQ)(phen)(H2O)Cl2] , and [YbIII(NQ)(phen)(H2O)Cl2] exhibit high antiproliferative activity against cisplatin-resistant A549/DDP cells (IC50 = 0.025-0.097 μM) and low toxicity to normal HL-7702 cells. Moreover, complex [SmIII(NQ)(phen)(H2O)Cl2], and to a lesser extent [YbIII(NQ)(phen)(H2O)Cl2], can upregulate the expression of LC3 and Beclin1 and downregulate p62 to induce apoptosis in cisplatin-resistant A549/DDP cell lines, which is related to the cell autophagy-inducing properties of [SmIII(NQ)(phen)(H2O)Cl2] and [YbIII(NQ)(phen)(H2O)Cl2]. Furthermore, in vivo assays suggest that [SmIII(NQ)(phen)(H2O)Cl2] significantly inhibits A549/DDP xenograft tumor growth (56.5%). These results indicate that lanthanide(III) complex [SmIII(NQ)(phen)(H2O)Cl2] is a promising candidate as an anticancer drug against cisplatin-resistant A549/DDP cells.

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