Category: 1127-45-3

de la Guardia, Carolina; Stephens, David E.; Dang, Hang T.; Quijada, Mario; Larionov, Oleg V.; Lleonart, Ricardo published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).Related Products of 1127-45-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of mols. with various biol. activities. Two of the tested compounds showed dose-dependent inhibition of dengue virus serotype 2 in the low and sub micromolar range. The compounds 1 and 2 were also able to impair the accumulation of the viral envelope glycoprotein in infected cells, while showing no sign of direct virucidal activity and acting possibly through a mechanism involving the early stages of the infection. The results are congruent with previously reported data showing the potential of quinoline derivatives as a promising scaffold for the development of new antivirals against this important virus.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.Product Details of 1127-45-3.Zhao, Wei; Yang, Chunxia; Ding, Yong; Ma, Baochun published the article 《The oxidation of pyridines catalyzed by surfactant-encapsulated polyoxometalate [(C18H37)2(CH3)2N]8[HBW11O39] with the temperature-responsive property of solubility》 about this compound( cas:1127-45-3 ) in New Journal of Chemistry. Keywords: oxidation pyridine catalyzed surfactant encapsulated polyoxometalate solubility. Let’s learn more about this compound (cas:1127-45-3).

Temperature-responsive characterization of solubility based on a surfactant-encapsulated polyoxometalate ([(C18H37)2(CH3)2N]8[HBW11O39]) in tert-Bu alc. was described and used in catalytic oxidation of pyridines. The catalyst could be recovered and reused several times by controlling the temperature

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Recommanded Product: 1127-45-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Synthesis of a new chiral selector base on pracoterol for chiral stationary phase. Author is Zhang, Yiwen; Zeng, Hao; Yao, Shun; Song, Hang.

According to the chiral resolution mechanism and structures of Pirkle’s chiral stationary phase (CSP), a new amide chiral selector base on pracoterol was prepared in this thesis. To get a better yield, all the conditions and purification conditions of the reactions were studied, and the key products were characterized by HPLC, FTIR and 1H NMR. This chiral selector may be developed as chiral selector of CSP.

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Brzezinski, Bogumil; Zundel, Georg published the article 《Proton polarizability of intramolecular hydrogen bonds with molecules nonconjugated and conjugated between donor and acceptor groups》. Keywords: proton polarizability hydrogen bond; IR proton polarizability conjugation; NMR proton polarizability conjugation.They researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Application of 1127-45-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1127-45-3) here.

IR and NMR spectroscopy was used to study proton polarizability in compounds [o-RC6H4CO2H, R = Me2NCH2 or Me2N; I, R1 = CH2OH or OH; and II] with intramol. H bonds. When the H-bond donor and acceptor groups are not electronically conjugated, IR continua indicate a large proton polarizability. When they are conjugated the continua are very weak. Thus, not only the proton potential but also the dependence of the dipole moment on the vibrational coordinate is decisive for occurrence of the continua.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.Synthetic Route of C9H7NO2.Larionov, Oleg V.; Stephens, David; Mfuh, Adelphe M.; Arman, Hadi D.; Naumova, Anastasia S.; Chavez, Gabriel; Skenderi, Behije published the article 《Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles》 about this compound( cas:1127-45-3 ) in Organic & Biomolecular Chemistry. Keywords: oxidation nitrogen heterocycle phosphomolybdic acid catalyst; nitrogen heterocycle oxide preparation. Let’s learn more about this compound (cas:1127-45-3).

A Mo/P catalytic system for an efficient gram-scale oxidation of a variety of nitrogen heterocycles to N-oxides with hydrogen peroxide as terminal oxidant has been investigated. Combined spectroscopic and crystallog. studies point to the tetranuclear Mo4P peroxo complex as one of the active catalytic species present in the solution Based on this finding an optimized catalytic system has been developed. The utility and chemoselectivity of the catalytic system has been demonstrated by the synthesis of over 20 heterocyclic N-oxides.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Hydroxyquinoline 1-oxide(SMILESS: OC1=CC=CC2=CC=C[N+]([O-])=C12,cas:1127-45-3) is researched.Formula: C9H11Br. The article 《Some reactions of 8-quinolinol N-oxide with bis(η5-cyclopentadienyl)titanium dichloride》 in relation to this compound, is published in Journal of the Indian Chemical Society. Let’s take a look at the latest research on this compound (cas:1127-45-3).

Treating a mixture of (ε5-C5H5)2TiCl2 (I) and 8-quinolinol N-oxide (II) with NaNH2 in PhMe under reflux gave (ε5-C5H5)2TiLCl (L = N-oxido-8-quinolinolato). Treating a mixture of I and II in MeCN with Et3N gave (ε5-C5H5)2TiL2 (same L).

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Recommanded Product: 8-Hydroxyquinoline 1-oxide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about DFT studies of the structure and vibrational spectra of 8-hydroxyquinoline N-oxide. Author is Dziembowska, T.; Szafran, M.; Jagodzinska, E.; Natkaniec, I.; Pawlukojc, A.; Kwiatkowski, J. S.; Baran, J..

The geometry, frequency and intensity of the vibrational bands of 8-hydroxyquinoline N-oxide (8-HQNO) and its deuterated derivative (8-DQNO) were obtained by the d. functional theory (DFT) with the BLYP and B3LYP functionals and 6-31G(d,p) basis set. The optimized bond lengths and bond angles are in good agreement with the X-ray data. The IR and INS spectra of 8-HQNO and 8-DQNO computed at the DFT level reproduce the vibrational wavenumbers and intensities with an accuracy, which allows reliable vibrational assignments.

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Brzezinski, Bogumil; Zundel, Georg published the article 《Influence of solvents on intramolecular hydrogen bonds with large proton polarizability》. Keywords: hydrogen bond intramol NMR; proton polarizability hydrogen bond NMR.They researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).SDS of cas: 1127-45-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1127-45-3) here.

A large number of compounds with intramol. hydrogen bonds with great proton polarizability were studied by 1H NMR in solvents of various polarities. With the homoconjugated hydrogen bonds, small changes of the chem. shift of the hydrogen-bonded proton are observed with increasing polarity of the solvent, whereby the signal shifts toward lower field. This effect is explained by increasing removal of the counterions from the homoconjugated hydrogen bonds and thus, by decreasing induced dipole interaction of the counterions and the hydrogen bonds with great proton polarizability. In the case of heteroconjugated hydrogen bonds analogous but much greater shifts are observed They are explained by a shift of the OH···N ⇌ O-···H+N equilibrium to the right-hand side with increasing polarity of the solvent. With hydrogen bonds showing no great proton polarizability these effects do not occur.

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Yang, Kai; Qiu, Yatao; Li, Zheng; Wang, Zhaoyang; Jiang, Sheng published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).Recommanded Product: 1127-45-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

Several new ligands were designed to promote copper-catalyzed Ullman C-N coupling reactions. In this group, 8-hydroxyquinoline-N-oxide was found to serve as a superior ligand for CuBr-catalyzed coupling reactions of aryl iodides, bromides, and chlorides with aliphatic amines and N-heterocycles under a low catalyst loading (1% [Cu] mol). Reactions with the inexpensive catalytic system display a high functional group tolerance as well as excellent chemoselectivity.

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Desiderato, R.; Terry, J. C.; Freeman, G. R.; Levy, H. A. published the article 《Molecular and crystal structure of 8-hydroxyquinoline N-oxide》. Keywords: structure quinolinol oxide.They researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Category: quinoxaline. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1127-45-3) here.

The structure of 8-hydroxyquinoline N-oxide was determined from diffractometer data by a direct method. The compound crystallizes in the monoclinic system with space group P21/c. The cell data are: a 12.1364(4), b 4.9211(2), c 13.1384(4) Å, β 109.26(1)°, d.(calculated)=1.449, d.(exptl.)=1.46, Z=4. The structure was solved by a direct method. 1528 reflections were used in a full-matrix least-squares refinement. R was reduced to a final value of 0.053. Bond lengths between non-H atoms have estimated standard derivations (e.s.d.’s) between 0.002 and 0.003 Å. The e.s.d.’s of the various bond angles (non-H atoms) range from 0.01 to 0.02°. Distances and angles involving the H atoms have e.s.d.’s of 0.02 Å and 1°, resp. The 2 C-N distances of the quinoline ring are unusually long, and the quinoline moiety is surprisingly similar to naphthalene in terms of bond distances and angles. The inductive effect of the N-O group may in part be responsible for the C-N lengthenings. The hydroxyl H atom is bonded to the dative O atom via a short intramol. H bond. The direct relation between the N-O dative bond distance and the strength of a H bond to the dative O atom appears to be substantiated in this study.

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