Category: 1127-45-3

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Application of unithiol (Na 2,3-dimercaptopropanesulfonate) in analytical chemistry》. Authors are Vol’f, A. L..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).COA of Formula: C9H7NO2. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

Unithiol (I) (cf. Ptrun’kin, CA 51, 5692h) forms stable complexes with many cations and most of these are soluble in H2O. Zn and Cd were determined by titration with I in the presence of Eriochrome Black T as an indicator with the same degree of accuracy as by titration with Trilon B; alkali metals and Fe up to 5 mg./l. did not interfere. I can be used to block the interference of Zn, Pb, and Hg in the trilonometric determination of Ca and Mg. I forms complexes with the following cations: in neutral media; Pb green, Cu blue, Ni brown, and Bi yellow; in acid media; Cu dark-blue, Ag green, and Mn brown; in NH4OH; Cu blue-violet, Fe red, Ag green, Mn brown-green, Bi yellow, and Sb yellow.

When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)COA of Formula: C9H7NO2 and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Heterocyclic N-oxides. V. Substitution reactions on 8-hydroxyquinoline 1-oxide》. Authors are Ramaiah, Kommineni; Srinivasan, Vankipuram R..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Recommanded Product: 8-Hydroxyquinoline 1-oxide. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

Nitration and halogenation of 8-hydroxyquinoline 1-oxide (I) having N-oxide and phenolic OH groups, each capable of orienting electrophilic substitution in the different rings, was studied with a view to knowing the relative directive influence of these groups and to screen the compounds obtained for bacteriostatic and fungistatic activity. Halogenation afforded under usual conditions products by substitution only in the benzene ring. Thus, 1.5 ml. SO2Cl2 in 10 ml. CHCl3 was added dropwise to a stirred solution of 0.8 g. I in 10 ml. CHCl3 at <5° to yield 0.92 g. 5,7-dichloro-8-hydroxyquinoline 1-oxide (II) as H2O-insoluble fraction (aqueous solution A), m. 203-4° (HOAc). Deoxygenation of II with PCl3 afforded 5,7-dichloro-8-hydroxyquinoline, m. 176°. The aqueous solution (A) on cooling yielded 0.07 g. 5-chloro-8-hydroxyquinoline 1-oxide, m. 169-70°. Similarly, bromination of 0.8 g. I in 10 ml. HOAc with 1 ml. Br in 10 ml. HOAc yielded 1.42 g. of the dibromo compound, m. 198-200° (HOAc), which on deoxygenation yielded 5,7-dibromo-8-hydroxyquinoline, m. 195°. Nitration of 0.8 g. I in 10 ml. HOAc with 2 ml. fuming HNO3 (d. 1.5) initially at room temperature and then 1 hr. at 70-80° (water-bath) yielded 0.8 g. 5,7-dinitro-8-hydroxyquinoline 1-oxide (III), m. 213-14° (HOAc). Nitration of 0.8 g. I in 10 ml. HOAc with 0.7 ml. concentrated HNO3 (d. 1.42) at <20° for 1 hr. yielded 0.75 g. 5-nitro-8-hydroxyquinoline 1-oxide (IV), m. 191-3° (EtOH). The structure of III and IV were established through deoxygenation and comparison with the known 5-nitro and 5,7-dinitro-8-hydroxyquinolines. The phenolic hydroxyl exerts greater influence than the N-oxide function. The usual 5,7-disubstituted derivatives of 8-hydroxyquinoline, 5,7-dihalo- or the 5,7-dinitro compounds were resistant to N-oxidation either by 30% H2O2-HOAc or BzO2H. When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)Recommanded Product: 8-Hydroxyquinoline 1-oxide and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Low-dimensional compounds containing bioactive ligands. Part XVI: Halogenated derivatives of 8-quinolinol N-oxides and their copper(II) complexes, published in 2021-12-15, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Quality Control of 8-Hydroxyquinoline 1-oxide.

Four N-oxides, 8-quinolinol N-oxide (8-HQNO), 5,7-dichloro-8-quinolinol N-oxide (HdClQNO), 5,7-dibromo-8-quinolinol N-oxide (HdBrQNO) and 7-iodo-8-quinolinol N-oxide (HIQNO) as well as their six copper complexes, CuCl2(8-HQNO)2(H2O) (1), CuCl2(HdClQNO)2(H2O)2 (2), Cu(dClQNO)2(CHCl3) (3), Cu(dClQNO)2(H2O) (4), {[Cu(dBrQNO)2]•2H2O}n (5) and CuCl2(HIQNO)2(H2O)4 (6) were synthesized as possible anticancer agents. Crystal structures of N-oxides contain planar mols. held together via hydrogen bonds involving oxygen atoms of N-oxide groups as acceptors. Crystal structure of 5 represents the first structure of a copper(II) complex with an N-oxide ligand derived from 8-HQNO and is formed by infinite chains. In the chain, the Cu(II) atom coordinates to six oxygen atoms from two bidentate chelating dBrQNO ligands occupying apexes of elongated tetragonal bipyramid with bridging oxygen atoms of N-oxide groups in axial positions. Antiproliferative activity of prepared N-oxides as well as their complexes was studied using in vitro MTT assay against the MDA-MB-231, HCT-116 and A549 cancer cell lines and their selectivity was verified on MSCs cells. Among the tested cancer cell lines, A549 and MDA-MB-231 cells were the most sensitive to the tested complexes. Complex 1 showed the highest cytotoxicity against both tumor cell lines. At concentration, which could be tested in animal models, 1 induced cell death in >50% of cancer cells and in 20% of MSCs indicating its selectivity.

When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)Quality Control of 8-Hydroxyquinoline 1-oxide and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bader, Mamoun M. published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).Synthetic Route of C9H7NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

The authors report herein the results of coupled perturbed Hartree-Fock (CPHF) ab initio extended basis set calculations on the geometric structures, dipole moments, static 1st-order (α), 2nd-order (β), and 3rd-order polarizabilities (γ) of fused heterocyclic aromatic compounds based on quinoline. The effects of the presence/absence of the heteroatom as well as the introduction of other substituents at various positions in the ring system on these mol. properties are described. The effect of the presence of N-oxide is also examined Suggestions for the design of heterocyclic systems with enhanced polarizabilities are made.

As far as I know, this compound(1127-45-3)Synthetic Route of C9H7NO2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Lun; Zhu, Changqing; Wu, Jialiang; Tong, Hongwu; Rao, Congshu; Zhang, Sujun published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).HPLC of Formula: 1127-45-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

8-Hydroxyquinoline N-oxide, synthesized in authors’ laboratory, is used as an energy receptor in Co(II)-H2O2 system and high intensity chemiluminescence of the system is observed A method for the measurement of trace Co is proposed. The detection limit and the relative standard deviation are 8.0 × 10-6 mg/mL and 3.2%, resp. Trace Co in copper ore, pig-liver, and shrimps is determined with satisfactory results. The possible mechanism of the chemiluminescence system is discussed.

As far as I know, this compound(1127-45-3)HPLC of Formula: 1127-45-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Computed Properties of C9H7NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Theoretical investigation of the second and third order nonlinear optical properties of some fused heterocyclic aromatic compounds. Author is Bader, Mamoun M..

The results of coupled perturbed Hartree-Fock (CPHF) ab initio extended basis set calculations on the geometric structures, dipole moments, static first-order (α), second-order (β), and third-order polarizabilities (γ) of fused heterocyclic aromatic compounds based on quinoline are reported. The effects of the presence/absence of the nitrogen atom as well as the introduction of other substituents (OH, NH2, NO2) at various positions in the ring system on these mol. properties are described. The effect of the presence of N-oxide is also examined Suggestions for the design of heterocyclic systems with enhanced polarizabilities are made.

As far as I know, this compound(1127-45-3)Computed Properties of C9H7NO2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.SDS of cas: 1127-45-3.Peiris, Dilrukshi M.; Lam, Wing; Michael, Steven; Ramanathan, Ragu published the article 《Distinguishing N-oxide and hydroxyl compounds: Impact of heated capillary/heated ion transfer tube in inducing atmospheric pressure ionization source decompositions》 about this compound( cas:1127-45-3 ) in Journal of Mass Spectrometry. Keywords: distinguishing nitrogen oxide hydroxyl mass spectra; heated capillary transfer tube pressure ionization source decomposition. Let’s learn more about this compound (cas:1127-45-3).

In the pharmaceutical industry, a higher attrition rate during the drug discovery process means a lower drug failure rate in the later stages. This translates into shorter drug development time and reduced cost for bringing a drug to market. Over the past few years, anal. strategies based on liquid chromatog./mass spectrometry (LC/MS) have gone through revolutionary changes and presently accommodate most of the needs of the pharmaceutical industry. Among these LC/MS techniques, collision induced dissociation (CID) or tandem mass spectrometry (MS/MS and MSn) techniques were widely used to identify unknown compounds and characterize metabolites. MS/MS methods are generally ineffective for distinguishing isomeric compounds such as metabolites involving oxygenation of carbon or nitrogen atoms. Most recently, atm. pressure ionization (API) source decomposition methods aid in the mass spectral distinction of isomeric oxygenated (N-oxide vs. hydroxyl) products/metabolites. In previous studies, experiments were conducted using mass spectrometers equipped with a heated capillary interface between the mass analyzer and the ionization source. The authors studied the impact of the length of a heated capillary or heated ion transfer tube (a newer version of the heated capillary designed for accommodating orthogonal API source design) in inducing for-API source deoxygenation that allows the distinction of N-oxide from hydroxyl compounds 8-Hydroxyquinoline (HO-Q), quinoline-N-oxide (Q-NO) and 8-hydroxyquinoline-N-oxide (HO-Q-NO) were used as model compounds on three different mass spectrometers (LCQ Deca, LCQ Advantage and TSQ Quantum). Irresp. of heated capillary or ion transfer tube length, N-oxides from this class of compounds underwent predominantly deoxygenation decomposition under atm. pressure chem. ionization conditions and the abundance of the diagnostic [M + H – O]+ ions increased with increasing vaporizer temperature Also, the results suggest that in API source decomposition methods described in this paper can be conducted using mass spectrometers with nonheated capillary or ion transfer tube API interfaces. Because N-oxides can undergo in-source decomposition and interfere with quantitation experiments, particular attention should be paid when developing API based bioanal. methods.

When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)SDS of cas: 1127-45-3 and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Synthesis of 2-Alkenylquinoline by Reductive Olefination of Quinoline N-Oxide under Metal-Free Conditions.Recommanded Product: 1127-45-3.

Synthesis of 2-alkenylquinoline by reductive olefination of quinoline N-oxide under metal-free conditions is disclosed. Practically, the reaction could be performed with quinoline as starting material via a one-pot, two-step process. A possible mechanism is proposed that involves a sequential 1,3-dipolar cycloaddition and acid-assisted ring opening followed by a dehydration process.

When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)Recommanded Product: 1127-45-3 and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Computed Properties of C9H7NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Complexation of dimethyltin(IV) ion with 2-mercaptopyridine N-oxide and 8-hydroxyquinoline N-oxide. Author is Singh, K. Ajit; Gupta, V. D..

Thermodn. parameters were determined for the complexation of Me2SnCl2 with the title N-oxides. In both cases ΔG and ΔH were neg.; ΔS was neg. for complexation with 2-mercaptopyridine N-oxide and pos. for complexation with 8-hydroxyquinoline N-oxide.

When you point to this article, it is believed that you are also very interested in this compound(1127-45-3)Computed Properties of C9H7NO2 and due to space limitations, I can only present the most important information.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called Ion-triggered multistate molecular switching device based on regioselective coordination-controlled ion binding, Author is Petitjean, Anne; Kyritsakas, Nathalie; Lehn, Jean-Marie, which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Related Products of 1127-45-3.

Mol. devices capable of accessing different controlled conformational states, while optically signaling the occupied state, are attractive tools for nanotechnol. since they relate to both areas of mol. mech. devices and logic gates. The authors report here a simple mol. system that allows access to four distinct conformational and optical states. It is based on the regioselective complexation of metal ions to a heterocyclic ligand triad, which is dictated by the accessible coordination geometry and electrostatic properties of two distinct binding subunits. Thus, local conformational switching is brought about by tetrahedral coordination (of CuI) or octahedral coordination (of M2+ ions) to bidentate and tridentate binding subunits, resp. The shape modifications undergone represent an ion-controlled nanomech. device. They give controlled access to four different states that display different physicochem. (e.g. optical) properties and provide a basis for logic gate operations.

As far as I know, this compound(1127-45-3)Related Products of 1127-45-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider