Category: 1127-45-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Palladium-Catalyzed Alkenylation of Quinoline-N-oxides via C-H Activation under External-Oxidant-Free Conditions, the main research direction is palladium catalyst stereoselective regioselective alkenylation quinoline oxide.Quality Control of 8-Hydroxyquinoline 1-oxide.

The direct cross-coupling of quinoline-N-oxides with olefin derivatives has been realized using palladium acetate as the catalyst in the absence of external ligand and oxidant to give the corresponding 2-alkenylated quinolines and 1-alkenylated isoquinolines chemo- and regioselectively in 27-95% yield. The catalytic process is proposed to proceed via direct C-H bond activation of the quinoline-N-oxide with Pd(OAc)2 followed by Heck coupling with the olefin. The resultant N-oxide of the alkenylated quinoline can oxidize the reduced Pd(0) to regenerate the Pd(II) active species and simultaneously release the 2-alkenylated quinoline without using any external oxidants and reductants.

This literature about this compound(1127-45-3)Quality Control of 8-Hydroxyquinoline 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Proc. Indian Acad. Sci. Sect. called Heterocyclic N-oxides. III. 8-Hydroxyquinoline N-oxide, Author is Ramaiah, K.; Srinivasan, V. R., which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Quality Control of 8-Hydroxyquinoline 1-oxide.

cf. CA 57, 6761f. Unlike 8-hydroxyquinoline (I), the title compound (II) shows no OH stretching at 3400 or 3660 cm.-1, Badger and Moritz (CA 53, 11382g). The broad medium-intensity band of II at 2857-2440 cm.-1 is independent of concentration and is interpreted as evidence of strong intramol. H bonding involving the O-H and N-O groups. Preliminary study by the method of Irving, et al. (CA 43, 8941i) with 23 cations indicates that II chelates more selectively than I. The results at pH 5.2, 8.4, and 12.4 are tabulated. II is conveniently prepared in fair yield by heating (water bath, 65-75°) 14.5 g. I in 30 ml. glacial HOAc with 10 ml. 30% H2O2. At intervals of 1 hr. a total of 30 ml. more of H2O2 was added in 3 equal increments. The mixture was concentrated in vacuo, made alk. with saturated aqueous Na2CO3, and left overnight after addition of 60 ml. CHCl3. Unreacted I was removed by steam distillation of the mixture after filtration, drying and removal of CHCl3 by distillation Hot filtration of the aqueous residue gave on cooling 5.96 g. yellow needles of II, m. 139°.

This literature about this compound(1127-45-3)Quality Control of 8-Hydroxyquinoline 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1127-45-3, is researched, Molecular C9H7NO2, about Theoretical investigation of the second and third order nonlinear optical properties of some fused heterocyclic aromatic compounds, the main research direction is second third order nonlinear property heterocyclic aromatic compound.Recommanded Product: 1127-45-3.

The authors report herein the results of coupled perturbed Hartree-Fock (CPHF) ab initio extended basis set calculations on the geometric structures, dipole moments, static 1st-order (α), 2nd-order (β), and 3rd-order polarizabilities (γ) of fused heterocyclic aromatic compounds based on quinoline. The effects of the presence/absence of the heteroatom as well as the introduction of other substituents at various positions in the ring system on these mol. properties are described. The effect of the presence of N-oxide is also examined Suggestions for the design of heterocyclic systems with enhanced polarizabilities are made.

This literature about this compound(1127-45-3)Recommanded Product: 1127-45-3has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Application In Synthesis of 8-Hydroxyquinoline 1-oxide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Hydrogen bonds in quinoline N-oxide derivatives: first-principle molecular dynamics and metadynamics ground state study.

Car-Parrinello mol. dynamics simulations were carried out for 8-hydroxyquinoline N-oxide (1) and 2-carboxyquinoline N-oxide (2) in vacuo and in the solid state. The first-principle approach was employed to intramol. hydrogen bond features present in the studied quinoline N-oxides. Grimme’s dispersion correction was employed throughout the study. Special attention was devoted to the solid-state computations knowing that in the mol. crystals, strong and weak interactions are responsible for spatial organization and mol. properties of mols. On the basis of Car-Parrinello mol. dynamics, it was possible to reproduce the hydrogen bond dynamics as well as to investigate the vibrational features on the basis of Fourier transform of the at. velocity autocorrelation function. The free energy surfaces for proton motion were reproduced by unconstrained CPMD runs as well as by metadynamics. Larger flexibility of the bridge proton in 2 was noticed. The computations are verified by exptl. X-ray and IR data available.

This literature about this compound(1127-45-3)Application In Synthesis of 8-Hydroxyquinoline 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1127-45-3, is researched, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2Journal, Sensor Letters called 2,8-Dihydroxyquinoline based sensitive fluoroionophore towards Cu2+ ion, Author is He, Chunlian; Li, Cheng; Li, Zhiguang; Li, Huanyin; Xiang, Jiannan; Yan, Zhengli, the main research direction is dihydroxyquinoline fluoroionophore copper ion determination.Product Details of 1127-45-3.

Novel water soluble quinoline derivatives 1a∼1d were synthesized from 8-hydroxyquinoline and the fluorescence of these compounds had been quenched by Cu2+ or Fe3+ in absolute water. The fluorescence of 1a was quenched by 93% with addition of 50 μM of Cu2+ in absolute water and 75% in the presence of 50 μM of Fe3+ with the quenching ratio (Cu2+:Fe3+) of 1:0.80, showing much higher sensitivity and selectivity of Cu2+ to Fe3+. The presence of some other metal ions such as K+, Ca2+, Zn2+, Al3+, Mn2+, Fe2+, Ba2+, Co2+, Ni+, Cr3+, Cd2+, Cu2+, Hg2+, Pb2+, Sn2+, Na+ and Mg2+ had little influence on the selectivity and sensitivity of Cu2+. The easily available 1a could be considered a potential fluorescence sensor for Cu2+.

As far as I know, this compound(1127-45-3)Product Details of 1127-45-3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Iodine-Catalyzed Direct C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes.Recommanded Product: 8-Hydroxyquinoline 1-oxide.

An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes catalyzed by iodine under metal- and external oxidant-free reaction conditions has been developed. A variety of (E)-2-styrylazaheterocycles have been produced in moderate to excellent yields. The mechanistic exploration indicated that the N-oxide group played dual roles as both the directing group and an internal oxidant in this catalytic cycle.

This literature about this compound(1127-45-3)Recommanded Product: 8-Hydroxyquinoline 1-oxidehas given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis and study of N-oxides of heterocyclic compounds. I. N-Oxides of derivatives of morphine, tetra-hydroisoquinoline, and quinoline》. Authors are Khaletskii, A. M.; Pesin, V. G.; Tsin, Chshou.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Product Details of 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

cf. Ochiai, C.A. 48, 3359i. Heating 8.4 g. codeine with 45 ml. 3% H2O2 at 50-60° gave after evaporation 8 g. codeine N-oxide, m. 206-8° (H2O); HCl salt, m. 214-17° (EtOH). To 5 g. dihydrohydroxycodeinone-HCl was added 10 ml. 10% NaOH yielding 93% dihydrohydroxycodeinone, m. 213-16°, which with 3% H2O2 as above gave 46.2% dihydrohydroxycodeinone N-oxide, decompose 152-3°, which gives a red color with Ac2O; picrate, m. 190-2°; HCl salt, m. 167-8°. The oxide treated with SO2 in warm EtOH gave 62.5% C18H23O8NS, decompose 169-70°, which was evidently an isomer of dihydrohydroxycodeinone sulfate; with BaCl2 solution it readily gave BaSO4; hydrolysis with 10% NaOH gave the original dihydrohydroxycodeinone, m. 207-9° (sulfate, m. 138-9°). Salsolidine (3 g.) in 20 ml. Me2CO and 30 ml. H2O treated with 2.5 ml. 30% H2O2 after several days at room temperature gave 15.48% N-hydroxysalsolidine, m. 100-1° (aqueous EtOH), which reduced Fehling and Tollens reagents. Similarly, N-methylsalsolidine gave N-methylsalsolidine N-oxide picrate, m. 133-4° (aqueous EtOH); HCl salt analog, decompose 162-3°. Oxidation of salsoline with 3% H2O2 in AcOH or with BzO2H in CHCl3 either gave no reaction or failed to yield any definite products. N-Methylsalsoline with aqueous H2O2 at room temperature in 3 days gave N-methylsalsoline N-oxide, m. 183° (EtOH); HCl salt, m. 186°. Oxidation of 8-hydroxyquinoline in CHCl3 with BzO2H with cooling gave yellow 8-hydroxyquinoline N-oxide, m. 137-8° (H2O); the same formed on oxidation with 30% H2O2 in AcOH-Ac2O at 40-5° in 3 hrs., but with 30% H2O2-AcOH in 2 hrs. only the starting material was recovered. 8-Hydroxyquinoline N-oxide treated with alc. KOH and Etl at reflux gave 8-ethoxyquinoline N-oxide, isolated as picrate, m. 135-8°; the same formed on treatment of 8-ethoxyquinoline with AcOH-Ac2O-30% H2O2 at 45-50°; HCl salt, m. 158°; free oxide, m. 61-2°. Similarly 2-phenylquinoline-4-carboxylic acid and AcOH-H2O2 gave 76% N-oxide, m. 244°, and 15% benzoylanthranilic acid, m. 170-2°. Oxidation of 2-phenylquinoline-4-carboxylic acid with BzO2H in CHCl3 in 2 days gave no evident reaction, the same being true of oxidation with 25% H2O2 in EtOH-Me2CO at 50°. Reduction of 2-phenylquinoline-4-carboxylic acid N-oxide with Na hydrosulfite in aqueous EtOH gave the original 2-phenylquinoline-4-carboxylic acid, m. 205-7°.

This literature about this compound(1127-45-3)Product Details of 1127-45-3has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Palladium-Catalyzed Alkenylation of Quinoline-N-oxides via C-H Activation under External-Oxidant-Free Conditions, the main research direction is palladium catalyst stereoselective regioselective alkenylation quinoline oxide.Formula: C9H7NO2.

The direct cross-coupling of quinoline-N-oxides with olefin derivatives has been realized using palladium acetate as the catalyst in the absence of external ligand and oxidant to give the corresponding 2-alkenylated quinolines and 1-alkenylated isoquinolines chemo- and regioselectively in 27-95% yield. The catalytic process is proposed to proceed via direct C-H bond activation of the quinoline-N-oxide with Pd(OAc)2 followed by Heck coupling with the olefin. The resultant N-oxide of the alkenylated quinoline can oxidize the reduced Pd(0) to regenerate the Pd(II) active species and simultaneously release the 2-alkenylated quinoline without using any external oxidants and reductants.

This literature about this compound(1127-45-3)Formula: C9H7NO2has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Hydroxyquinoline 1-oxide(SMILESS: OC1=CC=CC2=CC=C[N+]([O-])=C12,cas:1127-45-3) is researched.Formula: C9H7NO2. The article 《Molecular and crystal structure of 8-hydroxyquinoline N-oxide》 in relation to this compound, is published in Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry. Let’s take a look at the latest research on this compound (cas:1127-45-3).

The structure of 8-hydroxyquinoline N-oxide was determined from diffractometer data by a direct method. The compound crystallizes in the monoclinic system with space group P21/c. The cell data are: a 12.1364(4), b 4.9211(2), c 13.1384(4) Å, β 109.26(1)°, d.(calculated)=1.449, d.(exptl.)=1.46, Z=4. The structure was solved by a direct method. 1528 reflections were used in a full-matrix least-squares refinement. R was reduced to a final value of 0.053. Bond lengths between non-H atoms have estimated standard derivations (e.s.d.’s) between 0.002 and 0.003 Å. The e.s.d.’s of the various bond angles (non-H atoms) range from 0.01 to 0.02°. Distances and angles involving the H atoms have e.s.d.’s of 0.02 Å and 1°, resp. The 2 C-N distances of the quinoline ring are unusually long, and the quinoline moiety is surprisingly similar to naphthalene in terms of bond distances and angles. The inductive effect of the N-O group may in part be responsible for the C-N lengthenings. The hydroxyl H atom is bonded to the dative O atom via a short intramol. H bond. The direct relation between the N-O dative bond distance and the strength of a H bond to the dative O atom appears to be substantiated in this study.

This literature about this compound(1127-45-3)HPLC of Formula: 1127-45-3has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《8-Hydroxy-1-methoxyquinoline methosulfate》. Authors are Krasavin, I. A.; Dziomko, V. M.; Radin, Yu. P..The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Synthetic Route of C9H7NO2. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

The crude title compound, not described previously, m. 126-8° (decomposition) and is very soluble in water, soluble in alcs., and insoluble in nonpolar solvents. Reaction with nucleophilic compounds gives 2-substituted 8-hydroxyquinolines. A mixture of 48.3 g. powd. 8-hydroxyquinoline 1-oxide (m. 138.5-39°) (Phillips, et al., CA 51, 11349a; Murase and Demura, CA 58 3390b, recrystallized twice from water and C6H6) and 37.9 g. freshly distilled Me2SO4 is warmed on a water bath 2 hrs. with reflux. The mass is cooled and stirred until crystallization, 200 ml. dry Et2O is added, and the mixture stirred until all material is hardened. The solid is washed with 50-100 ml. Et2O in a mortar after filtration, washed on the filter with Et2O, and dried in a vacuum desiccator. Yield 77.6-9.3 g. hygroscopic material. Recrystallization of 20 g. from EtOH-Et2O gave 3.67 g., m. 143-4.5°.

This literature about this compound(1127-45-3)Synthetic Route of C9H7NO2has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider