Category: 1127-45-3

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sen, Chiranjit; Ghosh, Subhash C. researched the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ).Synthetic Route of C9H7NO2.They published the article 《Transition-Metal-Free Regioselective Alkylation of Quinoline N-Oxides via Oxidative Alkyl Migration and C-C Bond Cleavage of tert-/sec-Alcohols》 about this compound( cas:1127-45-3 ) in Advanced Synthesis & Catalysis. Keywords: alkyl quinoline oxide regioselective preparation; quinoline oxide alc alkyl migration bond cleavage PIDA mediated; isoquinoline alkyl oxide regioselective preparation; alc isoquinoline oxide alkyl migration bond cleavage PIDA mediated; pyridine alkyl oxide regioselective preparation; oxide pyridine alc aalkyl migration bond cleavage PIDA mediated. We’ll tell you more about this compound (cas:1127-45-3).

An unprecedented C2-alkylation of quinoline N-oxide derivatives I [R1 = Me, Et; R2 = H, OH, HNC(O)Ph, etc.; R3 = H, 6-Me, 5-Br, etc.] via C-C bond activation of tert- and sec-alkyl alc. was described using hypervalent iodine (III) reagent PhI(OAc)2 (PIDA). This regioselective alkylation using mild hypervalent iodine reagents was more practical, operationally simple and transition metal-free. The reaction proceeded efficiently with a broad range of substrates including quinoline, isoquinoline, and pyridine N-oxides using a variety of tert-/sec- alcs. to afford compounds I, alkyl-benzo[h]quinoline-N-oxides, alkyl-pyridine-N-oxides and alkyl-isoquinoline-N-oxides. From exptl. outcome, a rationalized mechanism was proposed, mediated by PIDA.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3 ) is researched.COA of Formula: C9H7NO2.Kacens, J.; Cebure, A.; Neilands, O. published the article 《8-Hydroxyquinophthalone derivatives》 about this compound( cas:1127-45-3 ) in Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija. Keywords: hydroxyquinonaphthalone; quinophthalone hydroxy. Let’s learn more about this compound (cas:1127-45-3).

8-Acetoxyquinophthalone (I, R = Ac, X = H) (II) was prepared in 62% yield by reaction of 8-quinolinol oxide with 1,3-indandione in Ac2O. Analogously prepared was I (R = Ac, X = Cl) in 62% yield. Hydrolysis of the acetate gave the corresponding alcs. (I, R = H, (Cl). Treatment of II with SO2Cl2 gave indandione (III, X = H). Analogously III (X = C) was obtained.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Obshchei Khimii called Synthesis and study of N-oxides of heterocyclic compounds. I. N-Oxides of derivatives of morphine, tetra-hydroisoquinoline, and quinoline, Author is Khaletskii, A. M.; Pesin, V. G.; Tsin, Chshou, which mentions a compound: 1127-45-3, SMILESS is OC1=CC=CC2=CC=C[N+]([O-])=C12, Molecular C9H7NO2, Quality Control of 8-Hydroxyquinoline 1-oxide.

cf. Ochiai, C.A. 48, 3359i. Heating 8.4 g. codeine with 45 ml. 3% H2O2 at 50-60° gave after evaporation 8 g. codeine N-oxide, m. 206-8° (H2O); HCl salt, m. 214-17° (EtOH). To 5 g. dihydrohydroxycodeinone-HCl was added 10 ml. 10% NaOH yielding 93% dihydrohydroxycodeinone, m. 213-16°, which with 3% H2O2 as above gave 46.2% dihydrohydroxycodeinone N-oxide, decompose 152-3°, which gives a red color with Ac2O; picrate, m. 190-2°; HCl salt, m. 167-8°. The oxide treated with SO2 in warm EtOH gave 62.5% C18H23O8NS, decompose 169-70°, which was evidently an isomer of dihydrohydroxycodeinone sulfate; with BaCl2 solution it readily gave BaSO4; hydrolysis with 10% NaOH gave the original dihydrohydroxycodeinone, m. 207-9° (sulfate, m. 138-9°). Salsolidine (3 g.) in 20 ml. Me2CO and 30 ml. H2O treated with 2.5 ml. 30% H2O2 after several days at room temperature gave 15.48% N-hydroxysalsolidine, m. 100-1° (aqueous EtOH), which reduced Fehling and Tollens reagents. Similarly, N-methylsalsolidine gave N-methylsalsolidine N-oxide picrate, m. 133-4° (aqueous EtOH); HCl salt analog, decompose 162-3°. Oxidation of salsoline with 3% H2O2 in AcOH or with BzO2H in CHCl3 either gave no reaction or failed to yield any definite products. N-Methylsalsoline with aqueous H2O2 at room temperature in 3 days gave N-methylsalsoline N-oxide, m. 183° (EtOH); HCl salt, m. 186°. Oxidation of 8-hydroxyquinoline in CHCl3 with BzO2H with cooling gave yellow 8-hydroxyquinoline N-oxide, m. 137-8° (H2O); the same formed on oxidation with 30% H2O2 in AcOH-Ac2O at 40-5° in 3 hrs., but with 30% H2O2-AcOH in 2 hrs. only the starting material was recovered. 8-Hydroxyquinoline N-oxide treated with alc. KOH and Etl at reflux gave 8-ethoxyquinoline N-oxide, isolated as picrate, m. 135-8°; the same formed on treatment of 8-ethoxyquinoline with AcOH-Ac2O-30% H2O2 at 45-50°; HCl salt, m. 158°; free oxide, m. 61-2°. Similarly 2-phenylquinoline-4-carboxylic acid and AcOH-H2O2 gave 76% N-oxide, m. 244°, and 15% benzoylanthranilic acid, m. 170-2°. Oxidation of 2-phenylquinoline-4-carboxylic acid with BzO2H in CHCl3 in 2 days gave no evident reaction, the same being true of oxidation with 25% H2O2 in EtOH-Me2CO at 50°. Reduction of 2-phenylquinoline-4-carboxylic acid N-oxide with Na hydrosulfite in aqueous EtOH gave the original 2-phenylquinoline-4-carboxylic acid, m. 205-7°.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Syntheses of 8-hydroxyquinoline N-oxide and its metallic complex salts》. Authors are Murase, Ichiro.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).SDS of cas: 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

8-Hydroxyquinoline N-oxide (IH) was obtained by the direct oxidation of 8-hydroxyquinoline with AcOH + 30% H2O2 or phthalic monoperacid as yellow crystals m. 138°. Greenish yellow CuI2.H2O, greenish black (MnI)2O.H2O and brownish black FeI3 were obtained. Fe(II), Ni, Co, and Zn do not form complexes.

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Quality Control of 8-Hydroxyquinoline 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Chemiluminescent system of 8-hydroxyquinoline N-oxide-cobalt(II)-hydrogen peroxide. Author is Wang, Lun; Zhu, Changqing; Wu, Jialiang; Tong, Hongwu; Rao, Congshu; Zhang, Sujun.

8-Hydroxyquinoline N-oxide, synthesized in authors’ laboratory, is used as an energy receptor in Co(II)-H2O2 system and high intensity chemiluminescence of the system is observed A method for the measurement of trace Co is proposed. The detection limit and the relative standard deviation are 8.0 × 10-6 mg/mL and 3.2%, resp. Trace Co in copper ore, pig-liver, and shrimps is determined with satisfactory results. The possible mechanism of the chemiluminescence system is discussed.

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SDS of cas: 1127-45-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Standardized system for quantifying residual dirt on medical appliances cleansed in hospital washers-disinfectors: Dirt detection by different methods. Author is Sigler, K.; Gaskova, D.; Chladkova, K.; Knebl, R.; Wimmer, T.; Vacata, V.; Gebel, J..

An easy-to construct, easy-to-operate standardized system was developed for determining the residual biol. contamination of surgical instruments, endoscopes and other medical appliances subjected to hospital cleansing and/or disinfection. It consists of standard-sized pieces of glass, metal or endoscope plastic – dirt carriers – either bare or enclosed in truncated Eppendorf caps to simulate hard-to-access conditions. The surface of the carriers is covered with model dirt simulating biol. contamination and the carriers are then affixed to sturdy metal holders. Conventional model dirts were found to peel or flake off the carrier surface, lowering the precision of residual soil determination A newly developed model dirt consisting of liver mash, lactose and sunflower oil and exhibiting low tendency to peel off surfaces was therefore used. The whole setup was subjected to chem. or enzymic cleansing programs at elevated temperature in hospital washer-disinfectors of two types, and the residual dirt after cleansing was determined by three methods. The method using toxicant-doped dirt that quenches the luminescence of an indicator bacterium Photobacterium phosphoreum gave satisfactory data under laboratory conditions but with hospital-washed samples it exhibited excessive fluctuations caused by bacterium-dirt interactions and by phys. influences. Both other methods gave better results but displayed some process sensitivity. The luciferin-luciferase-based ATP bioluminescence assay sometimes gave low or even neg. dirt level values and showed a low effect of reduced dirt accessibility on cleansing of metal carriers. The Bradford protein assay showed about equal cleansing efficiency for both easily and poorly accessible carriers after enzymic cleansing. Our system can be used for determining low levels of residual contamination of medical appliances after cleansing/disinfection and assessing the efficiency of com. washer-disinfectors; its efficiency can be further increased by using a cleansing process-insensitive method for soil detection and quantification.

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HPLC of Formula: 1127-45-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Intramolecular hydrogen bonding in 8-quinolinol N-oxides, quinaldinic acid N-oxides and quinoline-2-carboxyamide N-oxide. Deuterium isotope effects on 13C chemical shifts. Author is Dziembowska, Teresa; Rozwadowski, Zbigniew; Hansen, Poul Erik.

Secondary isotope effects on 13C chem. shifts have been measured in a series quinolinols, quinaldinic acid N-oxides and quinoline-2-carboxyamide N-oxide. For 8-quinolinol N-oxides a good correlation was found between δOH and nΔC(OD) isotope effects. The OH and 13C chem. shifts and nΔC(OD) show very small temperature dependences. The primary isotope effects are small, pos. and temperature insensitive. Furthermore, they increase with increasing nΔC(OD). All features point towards a localized hydrogen bond in an asym. double well potential. The quinaldinic acid N-oxides show long-range isotope effects on 13C chem. shifts of both signs with 2ΔC=O(OD) rather small. The primary isotope effects of the quinaldinic acid N-oxide is of order of 0.5 ppm, whereas for its 4-ethoxy-derivative is smaller, ∼0.3 ppm. The OH chem. shifts resonate at the low field ∼18-20 ppm and the OH resonance is fairly broad at room temperature, especially for the 4-ethoxy-derivative The temperature effects on the chem. shifts, primary and secondary isotope effects are small. For quinaldinic acid N-oxides the asym. broad quasi-single potential is suggested.For quinoline-2-carboxyamide N-oxide the isotope effects are small, indicating rather weak hydrogen bond.

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Storz, Thomas; Marti, Roger; Meier, Roland; Nury, Patrice; Roeder, Michael; Zhang, Kesheng published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).Related Products of 1127-45-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

The first safe and efficient synthesis of the important building block 2-amino-8-hydroxyquinoline (1) is described. Starting from the readily available N-oxide of the cheap bulk chem. 8-hydroxyquinoline (2), the target compound is obtained in a two-step one-pot procedure in good overall yield (53-66%) and purity (>98%) on a kilogram scale without chromatog.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Molecular reorganization of selected quinoline derivatives in the ground and excited states-Investigations via static DFT, published in 2015-07-21, which mentions a compound: 1127-45-3, mainly applied to quantum chem ESIPT quinoline derivatives intramol hydrogen bond, Electric Literature of C9H7NO2.

Quinoline derivatives undergo internal reorganizations via the observed excited-state-induced intramol. proton transfer (ESIPT). Here, we report on computations for selected 12 quinoline derivatives possessing three kinds of intramol. hydrogen bonds. D. functional theory was employed for the current investigations. The metric and electronic structure simulations were performed for the ground state and first excited singlet and triplet states. The computed potential energy profiles do not show a spontaneous proton transfer in the ground state, whereas excited states exhibit this phenomenon. Atoms in Mols. (AIM) theory was applied to study the nature of hydrogen bonding, whereas Harmonic Oscillator Model of aromaticity index (HOMA) provided data of aromaticity evolution as a derivative of the bridge proton position. The AIM-based topol. anal. confirmed the presence of the intramol. hydrogen bonding. In addition, using the theory, we were able to provide a quant. illustration of bonding transformation: from covalent to the hydrogen. On the basis of HOMA anal., we showed that the aromaticity of both rings is dependent on the location of the bridge proton. Further, the computed results were compared with exptl. data available. Finally, ESIPT occurrence was compared for the three investigated kinds of hydrogen bridges, and competition between two bridges in one mol. was studied. (c) 2015 American Institute of Physics.

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He, Chunlian; Li, Cheng; Li, Zhiguang; Li, Huanyin; Xiang, Jiannan; Yan, Zhengli published an article about the compound: 8-Hydroxyquinoline 1-oxide( cas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12 ).HPLC of Formula: 1127-45-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1127-45-3) through the article.

Novel water soluble quinoline derivatives 1a∼1d were synthesized from 8-hydroxyquinoline and the fluorescence of these compounds had been quenched by Cu2+ or Fe3+ in absolute water. The fluorescence of 1a was quenched by 93% with addition of 50 μM of Cu2+ in absolute water and 75% in the presence of 50 μM of Fe3+ with the quenching ratio (Cu2+:Fe3+) of 1:0.80, showing much higher sensitivity and selectivity of Cu2+ to Fe3+. The presence of some other metal ions such as K+, Ca2+, Zn2+, Al3+, Mn2+, Fe2+, Ba2+, Co2+, Ni+, Cr3+, Cd2+, Cu2+, Hg2+, Pb2+, Sn2+, Na+ and Mg2+ had little influence on the selectivity and sensitivity of Cu2+. The easily available 1a could be considered a potential fluorescence sensor for Cu2+.

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