Category: 1196-57-2

Direct benzylation reactions from benzyl halides enabled by transition-metal-free photocatalysis was written by Xiang, Panjie;Sun, Kai;Wang, Shuang;Chen, Xiaolan;Qu, Lingbo;Yu, Bing. And the article was included in Chinese Chemical Letters in 2022.Product Details of 1196-57-2 This article mentions the following:

An SN²-based photochem. strategy using dithiocarbamate anion as catalyst was developed for the activation of benzyl halides, which are extremely challenging to be applied as radical precursors in visible light photocatalysis. With this transition-metal-free and oxidant-free protocol, the benzylation (or cyanomethylation) of various heterocycles including quinoxalin-2(1H)-ones, coumarin, 2-phenyl-2H-indazole, 1-methyl-5-phenylpyrazin-2(1H)-one, 1-(fluoromethyl)cinnolin-4(1H)-one, and 2,4-dibenzyl-1,2,4-triazine-3,5(2H,4H)-dione could be realized (46 examples, up to 98% yield). Importantly, some biol. relevant 3-benzylquinoxalin-2(1H)-ones were also be synthesized under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Product Details of 1196-57-2).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands.Product Details of 1196-57-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Aryl acyl peroxides for visible-light induced decarboxylative arylation of quinoxalin-2(1H)-ones under additive-, metal catalyst-, and external photosensitizer-free and ambient conditions was written by Xie, Long-Yong;Peng, Sha;Yang, Li-Hua;Peng, Cun;Lin, Ying-Wu;Yu, Xianyong;Cao, Zhong;Peng, Yu-Yu;He, Wei-Min. And the article was included in Green Chemistry in 2021.Quality Control of 2-Quinoxalinol This article mentions the following:

Aryl radicals were generated for the first time from cheap and easily available aryl acyl peroxides in eco-friendly Et acetate under ambient conditions and visible-light illumination in the absence of any additive, metal catalyst, or external photosensitizer. The present arylation of quinoxalin-2(1H)-ones was chemo- and regioselective, and provided good access to various 3-arylquinoxalin-2(1H)-ones. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Quality Control of 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. Quinoxaline and its analogues may also be formed by reduction of amino acids substituted 1,5-difluoro-2,4-dinitrobenzene (DFDNB),One study used 2-iodoxybenzoic acid (IBX) as a catalyst in the reaction of benzil with 1,2-diaminobenzene.Quality Control of 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Molecular oxygen-mediated radical alkylation of C(sp³)-H bonds with boronic acids was written by Yang, Le;Qiu, Zhihong;Wu, Jintao;Zhao, Jianyou;Shen, Tong;Huang, Xuan;Liu, Zhong-Quan. And the article was included in Organic Letters in 2021.Name: 2-Quinoxalinol This article mentions the following:

A direct and site-specific alkylation of (sp³)C-H bond with aliphatic boronic acid was achieved. By simply heating glycinate and amines together with alkylboronic acids under an oxygen atm., a variety of unnatural α-amino acids and peptides could be obtained in good yields. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Name: 2-Quinoxalinol).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Name: 2-Quinoxalinol

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Visible-light-promoted/PIFA-mediated direct C-H acylation of quinoxalin-2(1H)-ones with aldehydes was written by Ni, Hangcheng;Li, Yu;Deng, Jieyi;Shi, Xingzi;Pan, Qinhai. And the article was included in New Journal of Chemistry in 2021.Application of 1196-57-2 This article mentions the following:

A simple and mild synthesis of 3-acylated quinoxalinones I [R = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R¹ = H, Me, allyl, etc.] had been achieved via C-H acylation reaction of quinoxalin-2(1H)-ones with aldehydes as the radical precursors under visible-light irradiation A wide variety of functional groups could be incorporated into the products by employing diverse aldehydes and quinoxalin-2(1H)-one derivatives Also, this method was applied to the modification of natural mols. and pharmaceutically relevant compounds A mechanistic study revealed that an HAT process occurred in the acylation reaction for the generation of acyl radicals, and that PIFA ([bis(trifluoroacetoxy)iodo]benzene) acted both as the photosensitizer and oxidant in this reaction. In the experiment, the researchers used many compounds, for example, 2-Quinoxalinol (cas: 1196-57-2Application of 1196-57-2).

2-Quinoxalinol (cas: 1196-57-2) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Application of 1196-57-2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider