Category: 1204-75-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 3-hydroxyquinoxaline-2-carboxylic acid, 9(500 mg, 2.63 mmol), and amino nitrile 6 (406 mg, 2.63 mmol) in anhydrous DMF (36 mL) was cooled down to 0Cin an ice/NaCl bath. To the cold solution, EDC¡¤HCl (1.50 g,7.89 mmol) and HOBt (1.46 g, 10.8 mmol) were added portionwiseover 30 min. The reaction mixture was stirred atroom temperature overnight and concentrated under vacuum.The resulting residue was taken CH2Cl2 (50 mL), treatedwith 2N NaOH until pH 14, and extracted with CH2Cl2 (3 ¡Á50 mL). The aqueous layer was treated with 1N HCl until pH1, extracted with CH2Cl2 (3 ¡Á 50 mL), and washed with brine(2 ¡Á 50 mL). The combined organic extracts were dried overanhydrous Na2SO4, concentrated under reduced pressure andthe resulting solid residue was washed with pentane (3 ¡Á 20mL), to provide amido nitrile 10 (730 mg, 85% yield) as ayellow solid; mp 181-182C; IR (ATR) nu 3081 (O-H, N-Hst), 2241 (CN st), 1678 (C=O st); 1H NMR (400 MHz,CD3OD) delta 1.41-1.50 (m, 8H), 1.61-1.71 (m, 4H), 2.43 (t, J =7.2 Hz, 2H), 3.48 (t, J = 7.2 Hz, 2H), 7.38 (dd, J = 8.4 Hz,J? = 1.2 Hz, 1H), 7.43 (ddd, J = 8.4 Hz, J? = 7.2 Hz, J? = 1.2Hz, 1H), 7.67 (ddd, J = 8.4 Hz, J? = 7.2 Hz, J? = 1.2 Hz,1H), 7.98 (dd, J = 8.4 Hz, J? = 1.2 Hz, 1H); 13C NMR (100.6MHz, DMSO-d6) delta 16.1, 24.7, 26.3, 28.0, 28.1, 28.5, 28.9,38.7, 115.57, 115.60, 120.7, 123.8, 129.2, 131.2, 131.7,132.4, 153.9, 163.0; HRMS (ESI), calcd for (C18H22N4O2 +H+) 327.1816, found 327.1817., 1204-75-7

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Article; Artigas, Albert; Sola, Irene; Taylor, Martin C.; Clos, M. Victoria; Perez, Belen; Kelly, John M.; Munoz-Torrero, Diego; Letters in Organic Chemistry; vol. 15; 5; (2018); p. 455 – 461;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General Method 6: Preparation of (2-((3-chlorophenoxy)methyl)piperidin-1-yl)(3-hydroxyquinoxalin-2-yl)methanone (6-5); Step 1: A suspension of 3-hydroxy-2-quinoxaline carboxylic acid 6-1 (1.0 g, 5.26 mmol), thionyl chloride (4.6 mL, 63.1 mmol, 12.0 equiv) and catalytic DMF (50 muL) in 10 mL toluene was heated to 80 C. After 1 h of heating, the reaction mixture was cooled to room temperature and evaporated to dryness to yield 6-2. In a separate flask, 2-piperidine methanol (0.61 g, 5.26 mmol) and triethylamine (0.88 mL, 6.3 mmol, 1.2 equiv) in 10 mL CH2Cl2 was cooled to 0 C. To this mixture was added 6-2 dropwise. The reaction was allowed to stir at room temperature for 1 h after which was diluted with H2O (10 mL), extracted with CH2Cl2 (2¡Á10 mL), dried over Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography (20-40% EtOAc/hexanes) to produce compound 6-3., 1204-75-7

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (940 mg, 2.37 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (540 mg, 2.84 mmol) to afford the desired title compound (680 mg, yield 54%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.83 (1H, brs), 9.55 (1H, brs), 7.86 (1H, m), 7.61 (1H, m), 7.38 (2H, m), 7.28 (1H, m), 7.11 (3H, m), 4.90 (1H, dd, J=7.6 Hz, 7.1 Hz), 4.68 (1H, m), 3.99-3.80 (2H, m), 3.57-3.20 (2H, m), 2.05 (4H, m), 1.68 (1H, m), 0.94 (6H, d, J=6.4 Hz). IR (KBr)cm-1: 2960, 1690, 1640, 1505, 1240, 1160. MS (ESI, m/z): 533 (M+H)+. HRMS (ESI, m/z): 533.1998 (Calcd for C26H25F3N4O5: 533.2012). Anal. Calcd for C26H27F3N4O5: C, 58.64; H, 5.11; N, 10.52. Found: C, 58.28; H, 5.12; N, 10.51., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (113 mg, 0.382 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (72.7 mg, 0.382 mmol) to afford the desired title compound (92.8 mg, yield 51%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.67 (1H, brs), 10.17 (1H, brs), 8.05-7.96 (1H, m), 7.70-7.32 (3H, m), 7.04-6.84 (4H, m), 5.08 (1H, dd, J=7.6 Hz, 7.1 Hz), 4.53-4.46 (1H, m), 4.00-3.68 (4H, m), 2.38-2.09 (1H, m), 2.02-1.85 (4H, m), 1.17-1.07 (6H, m). IR (KBr)cm-1: 2960, 1690, 1630, 1505, 1210. MS (ESI, m/z): 467 (M+H)+. HRMS (ESI, m/z): 467.2170 (Calcd for C25H28FN4O4: 467.2095)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (108 mg, 0.350 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol) to afford the desired title compound (107 mg, yield 68%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.87 (1H, brs), 9.70 (1H, brs), 7.88 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.78 (2H, d, J=9.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.4 Hz), 7.19 (2H, dd, J=9.0 Hz, 2.6 Hz), 5.03 (1H, m), 4.83 (1H, m), 4.07-3.73 (2H, m), 3.57-3.17 (2H, m), 2.12-1.89 (2H, m), 1.78-1.47 (2H, m), 1.31 (3H, d, J=7.0 Hz). IR (KBr) cm-1: 2945, 2220, 1685, 1640, 1605, 1505, 1255. MS (ESI, m/z): 446 (M+H)+. HRMS (ESI, m/z): 446.1851 (Calcd for C24H24N5O4: 446.1828)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Hydroxy-2-quinoxalinecarboxylic acid (3.00 g, 15.8 mmol) was dissolved in DMF (50 mL), followed by addition of 4-dimethylaminopyridine (2.12 g, 17.4 mmol). The reaction mixture was stirred at rt until the 4-dimethylaminopyridine dissolved, at which point N,N?-disuccinimidyl carbonate (4.45 g, 17.4 mmol) was added. The reaction mixture was stirred at rt for 30 min (Check HPLC to confirm reaction completion. If the reaction was not complete, additional 0.1 eq portions of DSC were added until HPLC showed complete conversion). A soln. of N-Boc-ethylenediamine (3.04 g, 19.0 mmol) and triethylamine (2.40 g, 3.30 mL, 23.7 mmol) in DMF (10 mL) was then added, and the reaction was stirred at rt for 1 h (check HPLC for reaction completion). The reaction mixture was then poured onto a vigorously stirring soln. of 1M HCl (250 mL). The resulting precipitate was collected by vacuum filtration, washed several times with water, and dried under high-vacuum, giving compound 5 as a yellow solid (5.10 g, 97% yield)., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ventana Medical Systems, Inc.; Belosludtsev, Yuri; DeGeer, Traci D.; French, Wendy J.; Hao, Junshan; Kelly, Brian D.; Murillo, Adrian E.; Polaske, Nathan W.; (55 pag.)US2018/186821; (2018); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (113 mg, 0.350 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (68.6 mg, 0.350 mmol) to afford the desired title compound (107 mg, yield 66%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.85 (1H, brs), 9.56 (1H, m), 7.87 (1H, dd, J=8.2 Hz, 7.8 Hz), 7.78 (2H, d, J=9.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.40 (1H, d, J=7.4 Hz), 7.38 (1H, d, J=8.2 Hz), 7.19 (2H, dd, J=9.0 Hz, 4.2 Hz), 5.00 (1H, m), 4.83 (1H, m), 4.07-3.81 (2H, m), 3.61-3.16 (2H, m), 2.14-1.46 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2965, 2220, 1685, 1630, 1505, 1250. MS (ESI, m/z): 460 (M+H)+. HRMS (ESI, m/z): 460.1973 (Calcd for C25H26N5O4: 460.1984).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step 4: Starting material 8-4 (0.15 g, 0.45 mmol) was dissolved in DCM (0.5 mL) and TFA (0.5 mL). The resulting mixture was stirred at room temperature for 2 h. Solvent was removed to give desired compound 8-5. Compound 8-5,3-oxo-3,4-dihydroquinoxaline-2-carboxylic acid (100 mg, 0.52 mmol), HATU (250 mg, 0.66 mmol) and iPr2NEt (0.4 mL, 2.29 mmol) were mixed in DMF (2 mL). The resulting mixture was heated at 85 C. overnight. The mixture was cooled to room temperature and the solvent was removed. The residue was purified by column chromatograph (silica gel, gradient elution with 7 N NH3-methanol/DCM, 1:60, v/v to 7N NH3-methanol/DCM, 1:10, v/v) to give desired product 8-6 (M+1: 402.2).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (160 mg, 0.439 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (85.6 mg, 0.439 mmol) to afford the desired title compound (78.3 mg, yield 38%) as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.87 (1H, brs), 9.67 (1H, brs), 8.16 (1H, d, J=2.6 Hz), 7.88 (1H, m), 7.76-7.62 (2H, m), 7.40 (1H, d, J=7.0 Hz), 7.39 (1H, d, J=8.6 Hz), 6.95-6.83 (1H, m), 5.19 (1H, m), 4.79 (1H, m), 4.10-3.82 (2H, m), 3.59-3.14 (2H, m), 2.17-1.45 (4H, m), 1.28-1.17 (1H, m), 0.53-0.36 (4H, m). IR (KBr) cm-1: 2960, 1690, 1630, 1530, 1480. MS (ESI, m/z): 466(M+H)+. HRMS (ESI, m/z): 466.1882 (Calcd for C24H25FN5O4: 466.1891).

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Hqc (9.5 mg, 0.05 mmol) in 5 ml MeOH was slowly added into a 2 ml H2O solution of Zn(ClO4)2¡¤6H2O (18.7 mg, 0.05 mmol) resulting in the formation of a clear yellow solution. Colorless crystals suitable for X-ray analysis were obtained after the solution was allowed to stand for several days (Yield 53%). Anal. Calc. for C19H20N4O10Zn: C, 43.08; H, 3.81; N, 10.58. Found: C, 43.15; H, 3.69, N, 10.67%. IR (KBr)/cm-1: 3446(m), 2809(s), 1697(s), 1493(m), 1221(m), 1019(w), 954(w), 880(w),747(w), 593(m), 509(w), 483(w).

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Bo; Xiao, Hai-Yang; Yang, Li-Jun; Inorganica Chimica Acta; vol. 407; (2013); p. 274 – 280;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider