Category: 1204-75-7

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (100 mg, 0.290 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (60.0 mg, 0.290 mmol) to afford N-[(1S)-1-{[4-(4-fluorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]-3-hydroxy-N-methylquinoxaline-2-carboxamide (88.0 mg, yield 63%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.74 (1H, brs), 7.81 (1H, d, J=7.8 Hz), 7.67 (1H, d, J=7.3 Hz), 7.61 (1H, d, J=11.2 Hz, 7.3 Hz), 7.38-7.32 (1H, m), 7.15 -7.10 (2H, m), 7.05-7.02 (2H, m), 5.08 (1H, d, J=11.5 Hz), 4.65-4.55 (1H, m), 4.12-4.06 (2H, m), 3.96-3.79 (2H, m), 2.77 and 2.76 (3H, s), 2.07-1.24 (5H, m), 0.97 (3H, dd, J=6.4 Hz, 2.4 Hz), 0.92 (3H, dd, J=6.4 Hz, 3.2 Hz). IR (ATR) cm-1, 3460, 2960, 1685, 1640, 1505, 1455, 1205, 1055. MS (ESI, m/z): 503 (M+Na)+. Anal. Calcd for C26H29FN4O4: C, 64.99; H, 6.08; F, 3.95; N, 11.66. Found: C, 64.69; H, 6.16; F, 4.14; N, 11.38.

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stirred solution of Zn(ClO4)2¡¤6H2O (18.7 mg, 0.05 mmol) in H2O (2 mL) was added 1 equiv. of 4,4′-bpy (7.8 mg, 0.05 mmol) in CH3OH (5 mL). This was stirred for 5 min, and then a 5 mL CH3OH solution of Hqc (9.5 mg, 0.05 mmol) was added to the reaction mixture and then filtered to give an orange solution. Slow evaporation of the solvent at room temperature gave rise to colorless block single crystals suitable for X-ray single-crystal analysis after 2 weeks (Yield 42%). Anal. Calc. for C28H18N6O6Zn: C, 56.06; H, 3.02; N, 14.01. Found: C, 55.93; H, 3.09; N, 14.12%. IR (KBr)/cm-1: 3066(w), 1654(s), 1503(m), 1449(s), 1349(m), 1283(w), 1227(w), 1010(w), 820(w), 553(m), 442(w).

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Article; Xiao, Bo; Xiao, Hai-Yang; Yang, Li-Jun; Inorganica Chimica Acta; vol. 407; (2013); p. 274 – 280;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Methanol solution (70 cm3) of [RuHCl(CO)(PPh3)3] (0.2 g, 2¡Á10-4 mol)and 3-hydroxy-2-quinoxalinecarboxylic acid (0.05 g, ~2¡Á10-4 mol) wasrefluxed for 3 h. The crystals suitable for X-ray analysis were obtained byslow evaporation of the reaction mixture. Yield 82%. IR (KBr, n/cm-1):1945 (s, nRu-H), 1926 (s, nRu-CO), 1708 (s, nCOO/OH), 1641 (s, nC=N, nC=C). UV-VIS (solid state, l/nm): 475, 400, 350, 250. UV-VIS [methanol, l/nm(log e)]: 466.4 (2.52), 388.8 (3.14), 322.0 (3.70), 276.0 (4.03), 251.2(4.33), 207.2 (4.85). 1H NMR (400 MHz, CDCl3) d: 14.45 (s, OH), 13.89(s, OH), 8.68 (d, hqxc, J 8.7 Hz), 8.17 (d, hqxc, J 8.6 Hz), 7.69 (dd, 17 H,J 16.4 and 5.7 Hz), 7.64-7.10 (m, PPh3/hqxc), 6.93 (s, 4 H), -10.51 (t,HRu, J 19.1 Hz). 13C NMR (101 MHz, CDCl3) d: 173.12 (s), 158.68 (s),143.00 (s), 138.04 (s), 134.29 (s), 133.41 (dt, J 8.7 and 6.1 Hz), 132.16 (s),131.80 (dd, J 22.8 and 6.1 Hz), 131.44 (s), 128.09 (q, J 4.9 Hz), 127.76 (s),127.27 (s), 126.87 (s), 126.34 (s). 31P NMR (202 MHz, CDCl3) d: 43.69(s). Found (%): C, 65.25; H, 4.52; N, 3.27. Calc. for C46H36N2O4P2Ru (%):C, 65.48; H, 4.30; N, 3.32., 1204-75-7

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma?ecki, Jan G.; MaronI, Anna; Kusz, Joachim; Mendeleev Communications; vol. 25; 2; (2015); p. 103 – 105;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3- hydroxyquinoxaline-2-carboxylic acid (11.55 mmol, 1.0 eq.) in 10 mL of dry DMF was added EDAC (17.33 mmol, 1.5 eq.) and N-hydroxysuccinimide (17.33 mmol, 1.5 eq.) and the reaction stirred 16 hours under dry nitrogen. The reaction was filtered through a sintered glass funnel and the yellow precipitate washed 2 times with 2 mL DMF then dried under vacuum to give 3.25 g (11.3 mmol, 98%) of the active ester 1 as a yellow solid

1204-75-7, As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; VENTANA MEDICAL SYSTEMS, INC.; MURILLO, Adrian, E.; KOSMEDER, Jerome, W.; MAY, Eric; DAY, William; LEFEVER, Mark; PEDATA, Anne, M.; BIENIARZ, Christopher; MILLER, Phillip; WO2012/3476; (2012); A2;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (150 mg, 0.430 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (81.0 mg, 0.430 mmol) to afford the desired title compound (71.0 mg, yield 43%) as a white solid. 1H-NMR (CDCl3 400 MHz) delta: 12.77 and 10.14 (1H, brs), 8.14 (1H, t, J=4.9 Hz), 7.98 (1H, d, J=8.1 Hz), 7.66-7.50 (3H, m), 7.37 (1H, brs), 6.86 (1H, dd, J=11.7 Hz, 4.9 Hz), 6.73 (1H, t, J=8.8 Hz), 5.40-5.32 (1H, m), 5.09 (1H, t, J=7.1 Hz), 4.10-3.91 (2H, m), 3.82-3.62 (2H, m), 2.39-2.17 (1H, m), 2.12-1.98 (2H, m), 1.95-1.83 (2H, m), 1.11 (6H, d, J=6.6 Hz). IR (ATR) cm-1: 1685, 1630, 1525, 1470, 1430, 1270, 1250, 1215. MS (ESI, m/z): 450 (M+H)+. Anal. Calcd for C24H27N5O3¡¤0.75H2O: C, 62.26; H, 6.20, N, 15.13. Found: C, 61.95; H, 5.86; N, 15.15.

1204-75-7, The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1204-75-7, The resulting compound (317 mg, 1.00 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (190 mg, 1.00 mmol) to afford the desired title compound (358 mg, yield 79%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.86 (1H, brs), 9.56 (1H, m), 7.88 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.8 Hz), 7.40 (1H, d, J=7.8 Hz), 7.38 (1H, d, J=7.8 Hz), 7.14 (2H, m), 7.03 (2H, m), 5.00 (1H, m), 4.60 (1H, m), 4.03-3.79 (2H, m), 3.57-3.20 (2H, m), 2.07-1.44 (6H, m), 0.92 (3H, t, J=7.4 Hz). IR (KBr) cm-1: 2965, 1690, 1630, 1505, 1205. MS (ESI, m/z): 453 (M+H)+. HRMS (ESI, m/z): 453.1950 (Calcd for C24H26FN4O4: 453.1938) Anal. Calcd for C24H25FN4O4: C, 63.71; H, 5.57; N, 12.38; F, 4.20. Found: C, 63.67; H, 5.46; N, 12.42; F, 4.09.

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting compound (2.00 g, 6.84 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (1.48 g, 7.80 mmol) under nitrogen stream to afford the desired title compound (2.71 g, yield 85%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.88 (1H, s), 9.62 (1H, d, J=6.0 Hz), 7.87 (1H, dd, J=7.6 Hz, 2.0 Hz), 7.65 (1H, dt, J=7.6 Hz, 2.0 Hz), 7.40 (1H, dt, J=7.6 Hz, 2.0 Hz), 7.37 (1H, d, J=7.6 Hz), 7.12 (2H, m), 7.02 (2H, m), 4.76 (1H, q, J=8.4 Hz), 4.61 (1H, m), 4.12-3.80 (2H, m), 3.60-3.20 (2H, m), 2.08-1.88 (2H, m), 1.75-1.45 (2H, m), 1.23 (1H, dd, J=6.4 Hz), 0.53-0.38 (4H, m). MS (ESI, m/z): 465 (M+H)+. Anal. Calcd for C25H25FN4O4: C, 64.64; H, 5.42; N, 12.06. Found: C, 64.27; H, 5.30; N, 12.01.

1204-75-7, 1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various fields.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider