Category: 1204-75-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

The resulting compound (200 mg, 0.580 mmol) was condensed with 3-hydroxyquinoxaline-2-carboxylic acid (110 mg, 0.580 mmol) to afford the desired title compound (143 mg, yield 51%) as a pale yellow solid. 1H-NMR (CDCl3 400 MHz) delta: 12.90 and 10.21 (1H, brs), 8.05-7.97 (2H, m), 7.61 (1H, d, J=6.8 Hz), 7.58 (1H, m), 7.37 (1H, brs), 7.21-7.13 (2H, m), 5.14-5.07 (1H, m), 4.68 and 4.59 (1H, m), 4.34 (1H, d, J=11.7 Hz), 3.60-3.35 (2H, m), 3.10-2.96 (1H, m), 3.10-2.96 (1H, m), 2.38-2.29 (1H, m), 2.11-0.96 (5H, m), 1.12-1.09 (6H, m). IR (ATR) cm-1: 1680, 1630, 1595, 1525, 1505, 1475. MS (ESI, m/z): 479 (M+H)+. Anal. Calcd for C26H27FN4O4¡¤0.5H2O: C, 64.05; H, 5.79; N, 11.49. Found: C, 64.20; H, 5.58; N, 11.34.

1204-75-7 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid 71001, aquinoxaline compound, is more and more widely used in various.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1204-75-7,3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (230 mg, 1.20 mmol) and 1-hydroxybenzotriazole monohydrate (184 mg, 1.20 mmol) were added to a methylene chloride solution (10 ml) of the resulting compound (308 mg, 1.00 mmol) and 3-hydroxyquinoxaline-2-carboxylic acid (190 mg, 1.00 mmol), at room temperature, under nitrogen stream, followed by further addition of N-methylmorpholine (0.550 ml, 5.00 mmol), and stirring was carried out at room temperature overnight. The reaction solution was diluted with methylene chloride, followed by sequential washing with a saturated aqueous sodium hydrogencarbonate solution, a saturated aqueous ammonium chloride solution, water and saline, and then the resulting organic layer was dried over anhydrous sodium sulfate. After the organic layer was concentrated and the resulting residue was purified by a medium-pressure preparative liquid chromatograph (manufactured by Biotage, Inc., 25+M), the residue resulting from concentration was suspended in a mixed solvent of methylene chloride-ethyl acetate, the solid substance was collected by filtration to afford the desired title compound (126 mg, yield 26%) as a pale yellow solid. 1H-NMR (DMSO-d6, 400 MHz) delta: 12.83 (1H, brs), 9.52 (1H, d, J=7.8 Hz), 7.86 (1H, dd, J=7.4 Hz, 7.0 Hz), 7.65 (1H, dd, J=7.8 Hz, 7.4 Hz), 7.40 (1H, d, J=7.0 Hz), 7.38 (1H, d, J=7.4 Hz), 7.17-7.09 (2H, m), 7.07-6.99 (2H, m), 5.08 (1H, m), 4.60 (1H, m), 4.02-3.18 (4H, m), 2.11-1.84 (2H, m), 1.76-1.44 (5H, m), 0.96 and 0.92 (6H, d, J=6.6 Hz). IR (KBr) cm-1: 2955, 1685, 1640, 1505, 1205. MS (ESI, m/z): 481 (M+H)+. HRMS (ESI, m/z): 481.2268 (Calcd for C26H30FN4O4: 481.2251).

The synthetic route of 1204-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2258697; (2010); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider

1204-75-7, 3-Oxo-3,4-dihydroquinoxaline-2-carboxylic acid is a quinoxaline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4: A suspension of 3-hydroxy-2-quinoxaline carboxylic acid 6-1 (500 mg, 2.63 mmol) and thionyl chloride (2.3 mL, 31.6 mmol, 12.0 equiv) in 10 mL toluene was heated to 80 C. After 2 h of heating, the reaction mixture was cooled to room temperature and evaporated to dryness to yield the acid chloride 7-6. In a separate flask, piperidine 7-5 (0.55 g, 2.63 mmol) and triethylamine (0.73 mL, 5.26 mmol, 2.0 equiv) in 10 mL CH2Cl2 was cooled to 0 C. To this mixture was added the acid chloride 7-6 dropwise. The reaction was allowed to stir at room temperature for 3 h after which was diluted with H2O (10 mL), extracted with EtOAc (2¡Á10 mL), washed with sat. NaHCO3, dried over Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography (10-30% EtOAc/CH2Cl2) to produce 7-7 (R isomer).

As the paragraph descriping shows that 1204-75-7 is playing an increasingly important role.

Reference£º
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider