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An ultrasound-assisted nanocatalysis: Ag NPs/rGO nanocomposite catalyzed one-pot diastereoselective synthesis of functionalized tetrahydropyridines

Ag NPs decorated reduced graphene oxide (Ag NPs/rGO) composite was synthesized through one-pot protocol involving simultaneous reduction of GO and AgNO3 and characterized by X-ray diffraction, transmission electron microscope, scanning electron microscopy, ultraviolet-visible, Fourier transform infrared, Raman, CV, and energy dispersive X-ray analyses. Results indicated that Ag NPs (~30 nm) were unvaryingly distributed onto the surface of rGO with good dispersion capability that usually lacks in Ag NPs alone. These nanocomposites were exploited to study their catalytic activities toward the one-pot diastereoselective synthesis of functionalized tetrahydropyridines under ultrasonic irradiation (US). The catalytic activity of Ag NPs/rGO was about 22-fold higher under US as compared to conventional method. Antiselectivity, shorter reaction time, excellent yields, simple work-up procedure, and purification of products by non-chromatographic methods were inherent advantages of the protocol. The catalyst was reused up to four runs without an appreciable loss of catalytic activity.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N222 | ChemSpider

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Reference of 130345-50-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 130345-50-5, molcular formula is C9H6N2O, introducing its new discovery.

AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES

The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N196 | ChemSpider

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(5Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,4,6-TRICHLOROPHENYL)AMINO]-1,3-THIAZOL-4(5H)-ONE

Invented is the compound (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,4,6-trichlorophenyl)amino]-1 ,3-thiazol-4(5H)-one, and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are pharmaceutical compositions containg this compound, methods of preparing this compound and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are methods of using this compound as an inhibitor of hYAK3 proteins.

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Quinoxaline – Wikipedia,
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THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS

Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.

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Palladium/di-1-adamantyl-n-butylphosphine-catalyzed reductive carbonylation of aryl and vinyl halides

A general and efficient palladium-catalyzed reductive carbonylation with low catalyst loadings (0.5 mol % Pd or below) has been developed. The formylation of aryl and heteroaryl bromides proceeds smoothly in the presence of palladium/di-1-adamantyl-n-butylphosphine at ambient pressure of synthesis gas to afford the corresponding aromatic aldehydes in good yields and excellent selectivity. In addition, vinyl halides react under similar conditions to form alpha,beta-unsaturated aldehydes in good yield.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N220 | ChemSpider

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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery

Choline kinase alpha (ChoKalpha) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis. Since several inhibitors of ChoKalpha display antiproliferative activity in both cellular and animal models, this novel oncogene has recently gained interest as a promising small molecule target for cancer therapy. Here we summarize our efforts to further validate ChoKalpha as an oncogenic target and explore the activity of novel small molecule inhibitors of ChoKalpha. Starting from weakly binding fragments, we describe a structure based lead discovery approach, which resulted in novel highly potent inhibitors of ChoKalpha. In cancer cell lines, our lead compounds exhibit a dose-dependent decrease of phosphocholine, inhibition of cell growth, and induction of apoptosis at low micromolar concentrations. The druglike lead series presented here is optimizable for improvements in cellular potency, drug target residence time, and pharmacokinetic parameters. These inhibitors may be utilized not only to further validate ChoKalpha as antioncogenic target but also as novel chemical matter that may lead to antitumor agents that specifically interfere with cancer cell metabolism.

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Quinoxaline – Wikipedia,
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6-0-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: 1wherein R1, R2, R3, R4, R5, R6, X, X?, Y, and Y? are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

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Electric Literature of 130345-50-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 130345-50-5, molcular formula is C9H6N2O, introducing its new discovery.

NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Abeta aggregation, a degradative effect on Abeta aggregates, an inhibitory effect on beta-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N217 | ChemSpider

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6-O-carbamate-11,12-lacto-ketolide antimicrobials

6-O-Carbamate-11,12-lacto-ketolide antimicrobials of the formula: 1wherein R1, R2, R3 R7, and R8 are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

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Quinoxaline – Wikipedia,
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Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus

The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N227 | ChemSpider