With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13311-79-0,6-Methoxy-1,2,3,4-tetrahydroquinoxaline,as a common compound, the synthetic route is as follows.
General procedure: Dichloroacetyl chloride (2.4 mL, 24 mmol) was added dropwise to a suspension of 2 (10 mmol) and Na2CO3 (2.55g, 24 mmol) in benzene (30 ml) at room temp with stirring. The mixture was stirred continuously for 1 hr and then it was taken up in a mixture of water and EtOAc. The organic phase was washed with saturated NaCl aq, dried over anhyNa2SO4 and vacuum distillation gave the residue. Recrystallization of the residue with ethanol gave pure products 4a-f., 13311-79-0
13311-79-0 6-Methoxy-1,2,3,4-tetrahydroquinoxaline 12549514, aquinoxaline compound, is more and more widely used in various fields.
Reference£º
Article; Ye, Fei; Liu, Xin-Ying; Qu, Li-Hua; Fu, Ying; Zhao, Li-Xia; Qu, Hai-Hao; Indian Journal of Heterocyclic Chemistry; vol. 24; 2; (2014); p. 167 – 174;,
Quinoxaline – Wikipedia
Quinoxaline | C8H6N2 | ChemSpider