Category: 141234-08-4

Lyu, Xue-Li et al. published their research in Journal of Organic Chemistry in 2020 | CAS: 141234-08-4

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Electric Literature of C9H6N2O

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines was written by Lyu, Xue-Li;Huang, Shi-Sheng;Huang, Yuan-Qiong;Li, Yong-Qiang;Song, Hong-Jian;Liu, Yu-Xiu;Wang, Qing-Min. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C9H6N2O This article mentions the following:

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses com. available starting materials. Scale-up of the reaction and subsequent synthesis of tubulin polymerization inhibitor demonstrated its utilities. A plausible mechanism was proposed on the basis of the fact that a stable cycloacylrhodium intermediate complex could be used as catalyst, and the complex reacted stoichiometrically with (het)arylboronic acids. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Electric Literature of C9H6N2O).

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Electric Literature of C9H6N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Baraldi, Pier G. et al. published their research in Collection of Czechoslovak Chemical Communications in 1992 | CAS: 141234-08-4

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Recommanded Product: Quinoxaline-5-carbaldehyde

Synthesis and calcium antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine dicarboxylates was written by Baraldi, Pier G.;Budriesi, Roberta;Cacciari, Barbara;Chiarini, Alberto;Garuti, Laura;Giovanninetti, Giuseppe;Leoni, Alberto;Roberti, Marinella. And the article was included in Collection of Czechoslovak Chemical Communications in 1992.Recommanded Product: Quinoxaline-5-carbaldehyde This article mentions the following:

A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine (I, R1 = e.g., indol-2-yl, quinolin-4-yl, quinoxalin-5-yl, R1 = Me or Et) antagonists were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compounds of the series elicited weak calcium antagonist activity and were stronger neg. inotropic. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Recommanded Product: Quinoxaline-5-carbaldehyde).

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Recommanded Product: Quinoxaline-5-carbaldehyde

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Lyu, Xue-Li et al. published their research in Journal of Organic Chemistry in 2020 | CAS: 141234-08-4

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Electric Literature of C9H6N2O

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines was written by Lyu, Xue-Li;Huang, Shi-Sheng;Huang, Yuan-Qiong;Li, Yong-Qiang;Song, Hong-Jian;Liu, Yu-Xiu;Wang, Qing-Min. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C9H6N2O This article mentions the following:

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses com. available starting materials. Scale-up of the reaction and subsequent synthesis of tubulin polymerization inhibitor demonstrated its utilities. A plausible mechanism was proposed on the basis of the fact that a stable cycloacylrhodium intermediate complex could be used as catalyst, and the complex reacted stoichiometrically with (het)arylboronic acids. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Electric Literature of C9H6N2O).

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including antibacterial, antibiotic and antineoplastic, antifungal, anti-inflammatory and analgesic drugs. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Electric Literature of C9H6N2O

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

 

Baraldi, Pier G. et al. published their research in Collection of Czechoslovak Chemical Communications in 1992 | CAS: 141234-08-4

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Recommanded Product: Quinoxaline-5-carbaldehyde

Synthesis and calcium antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine dicarboxylates was written by Baraldi, Pier G.;Budriesi, Roberta;Cacciari, Barbara;Chiarini, Alberto;Garuti, Laura;Giovanninetti, Giuseppe;Leoni, Alberto;Roberti, Marinella. And the article was included in Collection of Czechoslovak Chemical Communications in 1992.Recommanded Product: Quinoxaline-5-carbaldehyde This article mentions the following:

A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine (I, R1 = e.g., indol-2-yl, quinolin-4-yl, quinoxalin-5-yl, R1 = Me or Et) antagonists were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacol. activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compounds of the series elicited weak calcium antagonist activity and were stronger neg. inotropic. In the experiment, the researchers used many compounds, for example, Quinoxaline-5-carbaldehyde (cas: 141234-08-4Recommanded Product: Quinoxaline-5-carbaldehyde).

Quinoxaline-5-carbaldehyde (cas: 141234-08-4) belongs to quinoxaline derivatives. Condensed heterocycles of quinoxalines have become attractive targets in synthetic and medicinal chemistry due to their significant biological activities. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.Recommanded Product: Quinoxaline-5-carbaldehyde

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider