Category: 1448-87-9

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CYCLOPENTYLBENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PSYCHOTIC AND COGNITIVE DISORDERS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, L, X, Ra, Rb, R1, R2 and R3 their preparation, pharmaceutical compositions containing them and their use in therapy.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N504 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 2-Chloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

N, N-disubstituted benzo-nitrogen heterocycles-2-amine compound and use thereof (by machine translation)

The invention mainly relates to an N,N-double substituted benzoazacyclo-2-amide compound and an application thereof. The N,N-double substituted benzoazacyclo-2-amide compound is a compound shown as formula I or a salt formed by a medical acid or alkali. The compound provided by the invention has strong inhibition activity on RhoA protease which is tightly related with cardiovascular and cerebrovascular diseases. The compound provided by the invention is hopeful to be developed into a RhoA protease small-molecule inhibitor type cardiovascular and cerebrovascular disease treatment medicine.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N462 | ChemSpider

Synthetic Route of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

(DPEPhos)Ni(mesityl)Br: An Air-Stable Pre-Catalyst for Challenging Suzuki-Miyaura Cross-Couplings Leading to Unsymmetrical Biheteroaryls

The successful application of (DPEPhos)Ni(mesityl)Br (C1) as a pre-catalyst in the Suzuki-Miyaura cross-coupling of heteroaryl chlorides or bromides and heteroaryl boronic acids is reported. The use of C1 in this context allows for such reactions to be conducted under mild conditions (2 mol% Ni, 25 C), including cross-couplings leading to unsymmetrical biheteroaryls. Successful transformations of this type involving problematic pyridinyl boronic acid substrates (10 mol% Ni, 60 C) are also described.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1448-87-9

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N680 | ChemSpider

Electric Literature of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Review£¬once mentioned of 1448-87-9

Transition metals in organic synthesis: Highlights for the year 2000

A review with 1811 references about transition metal catalyzed or mediated reactions and functional group preparations is presented.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N689 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: quinoxaline. Introducing a new discovery about 1448-87-9, Name is 2-Chloroquinoxaline

Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists

To generate novel human Orexin-2 Receptor (OX2R) antagonists, a spiropiperidine based scaffold was designed and a SAR study was carried out. Compound 4f possessed the highest OX2R antagonistic activity with an IC 50 value of 3 nM with 450-fold selectivity against Orexin-1 Receptor (OX1R).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: quinoxaline, you can also check out more blogs about1448-87-9

Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N586 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 2-Chloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

Amination of chloro-substituted heteroarenes with adamantane-containing amines

Amination of 3,6-dichloropyridazine, chloropyrazine, 2,3and 2,6-dichloropyrazines, 2-chloroquinoxaline, 1-chloroand 1,3-dichloroisoquinolines with various adamantane-containing amines characterized by different steric hindrances at the amino group was studied. The yields of the amination products depended on the structure of starting compounds. In the reactions of all the dichloroheteroarenes, selective substitution of only one chlorine atom took place, with the best yields being observed for 2,6-dichloropyrazine. In the reaction of 1,3-dichloroisoquinoline, the chlorine atom at position 1 was selectively substituted in up to 90% yield.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N510 | ChemSpider

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. category: quinoxalineIn an article, once mentioned the new application about 1448-87-9.

SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS

The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N506 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 2-Chloroquinoxaline, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

Regioselective halogenation of pyridinium N-(benzoazynyl) aminides as a way to produce N-benzyl-alpha-aminobenzoazines

The halogenation of pyridinium N-(benzoazynyl) aminides with N-halosuccinimides provides a mild and regioselective method to functionalize the negatively charged diazine moiety in most cases. In some examples, however, formation of other products is explained. Finally, alkylation of the exocyclic nitrogen and reduction of the N?N bond provides a simple and straightforward strategy to obtain functionalized N-benzyl-benzoazynyl-alpha-amines.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 2-Chloroquinoxaline, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1448-87-9, in my other articles.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N587 | ChemSpider

Reference of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

C-N coupling of indoles and carbazoles with aromatic chlorides catalyzed by a single-component NHC-nickel(0) precursor

A new and efficient nickel-based protocol for the N-arylation of indoles and carbazoles with aromatic chlorides, the least expensive of the aryl halides, is described. The procedure provides selectively N-(hetero)arylation products in good to high yields, in short reaction times and without adding an excess of ligands.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N673 | ChemSpider

Application of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer?s disease

Multitarget molecules are considered as an effective way for the treatment of AD, instead of the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety of studies indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted quinoxaline-hydrazone derivatives were synthesized, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity and MAOA/B inhibitory activity. Based on the experimental results, compound 5l exhibited good inhibitory potency on both AchE (IC50 = 0.028 ¡À 0.001 muM) and monoamine oxidase B (IC50 = 0.046 ¡À 0.002 muM). Molecular modeling studies showed that 5l could bind to the active site of AChE and MAO-B. Taken together, these results suggested that compound 5l might be a potential multifunctional agent for the treatment of AD.

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Reference£º
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N543 | ChemSpider