Category: 1448-87-9

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. SDS of cas: 1448-87-9In an article, once mentioned the new application about 1448-87-9.

Visible-Light-Promoted Transition-Metal-Free Phosphinylation of Heteroaryl Halides in the Presence of Potassium tert-Butoxide

A novel visible-light-promoted C-P bond formation reaction in the absence of both transition metal and photoredox catalysts is disclosed. By employing easily available and inexpensive heteroaryl chlorides/bromides as substrates, a variety of heteroaryl phosphine oxides were obtained in moderate to good yields. This strategy provides a simple and efficient route to heteroaryl phosphine oxides.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N731 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C8H5ClN2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

Pd-Catalyzed Synthesis of Piperazine Scaffolds under Aerobic and Solvent-Free Conditions

A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N668 | ChemSpider

Related Products of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility

We report the discovery of a novel series of 2-(3-alkoxy-1-azetidinyl) quinolines as potent and selective PDE10A inhibitors. Structure-activity studies improved the solubility (pH 7.4) and maintained high PDE10A activity compared to initial lead compound 3, with select compounds demonstrating good oral bioavailability. X-ray crystallographic studies revealed two distinct binding modes to the catalytic site of the PDE10A enzyme. An ex vivo receptor occupancy assay in rats demonstrated that this series of compounds covered the target within the striatum.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N675 | ChemSpider

Reference of 1448-87-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Article£¬once mentioned of 1448-87-9

THE FACILE SYNTHESIS OF QUINOXALINYL-2-OXYPHENOLS

Facile synthesis of quinoxalinyl-2-oxyphenols are described.The condensation of 2-chloroquinoxalines with three molar equivalent of dihydroxybenzene in basic medium gave preferentially quinoxalinyl-2-oxyphenols, which involves nucleophilic cleavage of the initially formed bis(quinoxalinyl-2-oxy)benzenes by an excess of dihydroxybenzene.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N678 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 2-Chloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

HFIP Promoted Low-Temperature SNAr of Chloroheteroarenes Using Thiols and Amines

A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N530 | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: quinoxaline. Introducing a new discovery about 1448-87-9, Name is 2-Chloroquinoxaline

Atomistic Simulation: A Unique and Powerful Computational Tool for Corrosion Inhibition Research

It is difficult to understand the atomistic information on the interaction at the metal/corrosion inhibitor interface experimentally which is a key to understanding the mechanism by which inhibitors prevent the corrosion of metals. Atomistic simulations (molecular dynamics and Monte Carlo) are mostly performed in corrosion inhibition research to give deeper insights into the mechanism of inhibition of corrosion inhibitors on metal surfaces at the atomic and molecular time scales. A lot of works on the use of molecular dynamics and Monte Carlo simulation to investigate corrosion inhibition phenomenon have appeared in the literature in recent times. However, there is still a lack of comprehensive review on the understanding of corrosion inhibition mechanism using these atomistic simulation methodologies. In this review paper, we first of all introduce briefly some important molecular modeling simulations methods. Thereafter, the basic theories of molecular dynamics and Monte Carlo simulations are highlighted. Several studies on the use of atomistic simulations as a modern tool in corrosion inhibition research are presented. Some mechanistic and energetic information on how organic corrosion inhibitors interact with iron and copper metals are provided. This atomic and molecular level information could aid in the design, synthesis and development of new and novel corrosion inhibitors for industrial applications.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N650 | ChemSpider

Reference of 1448-87-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a Review£¬once mentioned of 1448-87-9

alpha-Keto Acids: Acylating Agents in Organic Synthesis

A significant number of important acyl-transfer reactions, such as direct acylation, ortho acylation, heteroatom acylation, and a diversity of cyclization reactions using the title compound as a key starting material, have been described in recent years. Just like a sleeping beauty, alpha-oxocarboxylic acids were awakened from a 17-year sleep to become important reagents in classical and new acylation reactions. The greener characteristic of the coproduct formed in reactions using alpha-keto acid (only CO2), together with its versatility as a building block in catalytic organic synthesis, accredit it as a candidate to green acylating agent, an alternative to acyl chloride, and other acyl-transfer reagents. This review presents the impressive breakthroughs achieved mainly in the past decade in the development of new catalytic reactions for the formation of C-C, C-N, and C-S bonds using alpha-keto acids.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N655 | ChemSpider

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Oxidative addition of haloheteroarenes to palladium(0): Concerted versus SNAr-type mechanism

The kinetics of the oxidative additions of haloheteroarenes HetX (X=I, Br, Cl) to [Pd0(PPh3)2] (generated from [Pd0(PPh3)4]) have been investigated in THF and DMF and the rate constants have been determined. In contrast to the generally accepted concerted mechanism, Hammett plots obtained for substituted 2-halopyridines and solvent effects reveal a reaction mechanism dependent on the halide X of HetX: an unprecedented SNAr-type mechanism for X=Br or Cl and a classical concerted mechanism for X=I. These results are supported by DFT studies.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N619 | ChemSpider

Electric Literature of 1448-87-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2. In a article£¬once mentioned of 1448-87-9

AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are alphavbeta6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N492 | ChemSpider

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Iron-catalyzed Minisci acylation of N-heteroarenes with alpha-keto acids

An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with alpha-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic alpha-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N716 | ChemSpider