Category: 1448-87-9

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1448-87-9, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

13C Nuclear Magnetic Resonance Spectra of Quinoxaline Derivatives

The 13C n.m.r. spectra of a series of 5-, 6-, and 2-substituted quinoxalines have been analysed by consideration of their 1H coupled spectra.Typical values of the coupling constants are: C(2,3), 1JCH 181.9, 2JCH 11.4, C(5,8), 1JCH 162.6, 3JCH 6.5, C(6.7), 1JCH 159.4, 3JCH 9.1; C(9), 3JCH(2) = 3JCH(7) = 10.0, 3JCH(5) 5.4; C(10), 3JCH(3) = 3JCH(6) = 10.0, 3JCH(8) 5.4 Hz.The magnitudes of the coupling constants in the benzenoid ring are similar to these for the corresponding positions in naphthalene, but application of naphthalene chemical shift substitutions effects leads in some cases to the wrong peak sequence in the related quinoxalines.Within the quinoxaline series itself, however, acceptable additivity of substituent effects is found (+/- 0.8 p.p.m.), provided that the reference compounds are carefully chosen.Analysis of mixtures of quinoxalines from substituted o-phenylenediamines and alpha-oxo-aldehydes is possible by consideration of the multiplicity of the ring-junction quaternary carbon signals in the fully coupled spectra.

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Quinoxaline | C8H6N631 | ChemSpider

Application of 1448-87-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1448-87-9, molcular formula is C8H5ClN2, introducing its new discovery.

Cobalt-catalyzed C-N bond-forming reaction between N-aromatic 2-chlorides and secondary amines

Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved, The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C-N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain amount of versatility and functional group tolerance. Wiley-VCH Verlag GmbH & Co. KGaA.

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Quinoxaline | C8H6N706 | ChemSpider

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 2-Chloroquinoxaline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1448-87-9

Synthesis and antidiabetic activity of 3,6,7-trisubstituted-2-(1H-imidazol- 2-ylsulfanyl)quinoxalines and quinoxalin-2-yl isothioureas

Two series of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)- quinoxalines 2a-1 and 2-(quinoxalin-2-yl)-isothioureas 3a-1 were prepared. All the test compounds 2a-1 and 3a-1 were screened in vitro, in a RIN5F cell-based assay for glucose-dependent insulinotropic activity. A significant concentration and glucose-dependent insulin secretion effect was seen with compounds 2a-1 and the insulinotropic activity of compound 21 was found to be identical to that of the standard compound (6,7-dichloro-2-trifluromethyl-3-(5-methyl-1,3,4- thiadiazo-2-ylsulfanyl)-quinoxaline (1)).

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N519 | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C8H5ClN2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1448-87-9, Name is 2-Chloroquinoxaline, molecular formula is C8H5ClN2

Organoselenium compounds from purines: Synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect

We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities, and memory improvement effect. This class of compounds was synthesized in good yields by a reaction of 6-chloropurine with diaryl diselenides using NaBH4 as reducing agent and PEG-400 as solvent. Furthermore, the synthesized compounds were evaluated for their in vitro antioxidant and acetylcholinesterase (AChE) inhibitor activities. The best AChE inhibitor was assessed on the in vivo memory improvement. Our results demonstrated that the 6-((4-chlorophenyl)selanyl)-9H-purine and 6-(p-tolylselanyl)-9H-purine presented in vitro antioxidant effect. In addition, 6-((4-fluorophenyl)selanyl)-9H-purine inhibited the AChE activity and improved memory, being a promising therapeutic agent for the treatment of Alzheimer’s disease.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C8H5ClN2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1448-87-9, in my other articles.

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Quinoxaline | C8H6N575 | ChemSpider

Reference of 1448-87-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1448-87-9, molcular formula is C8H5ClN2, introducing its new discovery.

Certain imidazoquinoxalinols; a new class of GABA brain receptor ligands

The invention encompasses compounds of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: X and Y are hydrogen, halogen, hydroxy or amino with the proviso that at least X or Y is hydroxy; andR 1 -R 4 are variables representing various organic and inorganic substituents; andW representsphenyl, 2- or 3-thienyl, or 2-, 3-, or 4-pyridyl; or phenyl, 2- or 3-thienyl, or 2-, 3-, or 4-pyridyl, each of which is mono or disubstituted with various organic or inorganic substituents.These compounds or prodrugs thereof are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

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Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure

The synthesis and the biological evaluation of a series of novel pyrroloquinoxaline derivatives are described. In binding studies several compounds proved to be potent and selective 5-HT3 receptor ligands. The most active pyrroloquinoxalines, 11d and 11e, showed a subnanomolar affinity for 5-HT3 receptor and were able to functionally discriminate the central and peripheral 5-HT3 receptors, being agonists and antagonists, respectively. In functional studies ([14C]-guanidinium accumulation test in NG 108-15 cells, in vitro) most of the synthesized compounds showed clear-cut 5-HT3 agonist properties. In in vivo studies on the von Bezold-Jarisch reflex test (a peripheral interaction model) the behavior of the tested compounds ranged from agonist to antagonist, while clear agonist properties were obtained with 12a on cortical acetylcholine release in freely moving rats. Pharmacokinetic studies with 11e and 12c indicate that the compounds easily cross the blood- brain barrier (BBB) after systemic administration with a brain/plasma ratio of 17.5 and 37.5, respectively. Thus compounds 11e and 12c represent the most potent central 5-HT3 agonists identified to date that are able to cross the blood-brain barrier.

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BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS

Compounds having the structure of Formula Ia, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis

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Quinoxaline | C8H6N484 | ChemSpider

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TAUTOMERISM OF DERIVATIVES OF AZINES. 17. EFFECT OF SOLVENTS ON THE POSITION OF THE AZINYL-YLIDENE TAUTOMERIC EQUILIBRIUM OF SUBSTITUTED AZINYLMETHANES

The effect of solvents on the position of the azinyl-ylidene tautomeric equilibrium in series of azinylmethanes was studied.It was shown that an increase in the polarity of the solvent leads to stabilization of the ylidene tautomer; the sensitivity of the tautomeric equilibrium to the effects of the solvent depends on the form of the side fragment that undergoes tautomerization.It was concluded that stabilization of the ylidene tautomeric form by polar solvents is a general tendency in series of prototropic equilibrium of the azinyl-ylidene type as a whole.

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Quinoxaline | C8H6N659 | ChemSpider

1448-87-9, Name is 2-Chloroquinoxaline, belongs to quinoxaline compound, is a common compound. 1448-87-9In an article, authors is Armengol, once mentioned the new application about 1448-87-9.

Synthesis of thieno[2,3-b]quinoxalines and pyrrolo[1,2-a]-quinoxalines from 2-haloquinoxalines

The palladium(0)-catalysed coupling of 2-haloquinoxalines with functionally substituted alkynes, addition of one mol equivalent of bromine to the 2-alkynylquinoxalines thus produced and then reaction of the resulting dibromides with disodium trithiocarbonate produced 2-hydroxymethyl- and 2-(diethoxymethyl)thieno[2,3-b]quinoxalines. Addition of bromine to some 6-substituted-2-(3,3-diethoxypropyn-1-yl)quinoxalines gave pyrrolo[1,2-a]quinoxalines. Treatment of a 3-(1,2-dibromoalkenyl)quinoline, a 3-(1,2-dibromoalkenyl)pyrazine, and a 5-(1,2-dibromoalkenyl)-pyrimidine with disodium trithiocarbonate failed to induce thiophene ring formation.

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Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes

A mild, general, and highly efficient catalytic etherification protocol for chloroheteroarenes was developed using the Pd/PTABS catalytic system. The protocol is selective for the etherification of chloroheteroarenes using a large variety of electron-rich and electron-deficient phenol bearing synthons which include inter alia biologically and commercially important estrone, estradiol, tyrosine, and several other molecules. The mildness of the new protocol is expected to be beneficial for the synthesis of complex drugs and drug intermediates offering late-stage modification of bioactive compounds.

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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N529 | ChemSpider